PMID: 2871949Feb 1, 1986Paper

The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones

Clinical Endocrinology
B J LooijL H Rees

Abstract

To determine whether the 29 amino-acid fragment of growth hormone releasing hormone (GHRH) can be combined with other hypothalamic releasing hormones in a single test of anterior pituitary reserve, the responses of anterior pituitary hormones to combinations of an i.v. bolus of GHRH(1-29)NH2 or saline with an i.v. bolus of either LH releasing hormone (LHRH) plus TRH, ovine CRH(oCRH) or saline were studied. Each infusion of GHRH(1-29)NH2 resulted in a rapid increment of the plasma GH value. Infusion of GHRH(1-29)NH2 also caused a small and transient rise in plasma PRL, but no change in the integrated PRL response. The combination of GHRH(1-29)NH2 with LHRH plus TRH caused a larger increment of peak and integrated plasma TSH levels than LHRH plus TRH alone. GHRH(1-29)NH2 did not affect the release of other anterior pituitary hormones after infusion with oCRH or LHRH plus TRH. Because of the finding of potentiation of the TSH-releasing activity of LHRH plus TRH by GHRH(1-29)NH2, the study was extended to the investigation of TSH release after infusion of TRH in combination with either GHRH(1-29)NH2 or GHRH(1-40). In this study the combination of TRH with both GHRH preparations also caused a larger increment of the peak and integra...Continue Reading

References

Jul 1, 1971·Endocrinology·L H ReesR A Knight
Aug 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M C GelatoG R Merriam
Feb 1, 1984·The Journal of Clinical Endocrinology and Metabolism·O F AlmeidaG R Merriam
Nov 30, 1982·Biochemical and Biophysical Research Communications·W B WehrenbergR Guillemin

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Citations

Feb 1, 1992·Journal of Neurology·C P ZwetslootW Onkenhout
Apr 1, 1986·Klinische Wochenschrift·J SchopohlK von Werder
Nov 1, 1989·Journal of Endocrinological Investigation·F RoelfsemaM Frölich
Dec 1, 1989·Journal of Endocrinological Investigation·J Alba-RothK von Werder
Mar 1, 1995·Journal of Endocrinological Investigation·B J LooijJ P Schröder-van der Elst
Nov 1, 1988·Clinical Endocrinology·B J LooijA C Nieuwenhuijzen Kruseman
Aug 1, 1988·Clinical Endocrinology·J D ClarkO M Edwards
Aug 1, 1986·Clinics in Endocrinology and Metabolism·A GrossmanG M Besser
Jan 1, 1994·Clinical Oncology : a Journal of the Royal College of Radiologists·M WilliamsJ W Leer
Sep 1, 1988·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P F van der HeijdenJ Brownell
Jan 1, 1988·Clinical Endocrinology·C DieguezM F Scanlon
Dec 1, 1986·Journal of Endocrinological Investigation·M GiustiG Giordano
Jun 1, 1988·Journal of Endocrinological Investigation·G DelitalaR Virdis

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