The interaction of miconazole and ketoconazole with lipids

Biochemical Pharmacology
H Van den BosscheJ M van Cutsem

Abstract

Staphylococcus aureus can be protected by unsaturated unesterified fatty acids against the growth inhibitory effects of miconazole and ketoconazole observed at concentrations greater than 10(-6) M and greater than 10(-5) M, respectively. Miconazole's fungicidal activity is partly antagonized by oleic acid. However, the effect of ketoconazole on the viability of Candida albicans was not affected by this fatty acid. Cytochrome oxidase and ATPase activities are more sensitive to miconazole (10(-5) M) than to ketoconazole (greater than 10(-4) M) and also liposomes are more susceptible to lysis induced by miconazole. Using differential scanning calorimetry it is shown that high concentrations of miconazole shift the lipid transition temperature of multilamellar vesicles to lower values without affecting the enthalpy of melting. Ketoconazole induces a broadening of the main transition peak only. It is suggested that miconazole changes the lipid organization without binding to the lipids, whereas ketoconazole is localized in the multilayer without having an important direct effect on the lipid organization. The results indicate that miconazole, and to a lesser extent ketoconazole, at doses that can be reached by topical application on...Continue Reading

References

Dec 27, 1977·Biochemistry·S B Vik, R A Capaldi
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P L YeagleK Bloch
Apr 1, 1978·Chemico-biological Interactions·H van den BosscheL Le Jeune
Sep 29, 1978·Biochimica Et Biophysica Acta·H Sandermann
Nov 1, 1979·Antimicrobial Agents and Chemotherapy·I J SudD S Feingold
Mar 1, 1975·Sabouraudia·H Van Den BosscheJ M Van Cutsem
Sep 15, 1974·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·H Van den Bossche
Feb 21, 1980·Biochimica Et Biophysica Acta·F Defrise-QuertainM Delmelle
Jun 1, 1980·Antimicrobial Agents and Chemotherapy·H Van den BosscheJ M van Cutsem
Jul 1, 1981·Antimicrobial Agents and Chemotherapy·I J Sud, D S Feingold
Nov 16, 1981·Biochemical and Biophysical Research Communications·R BrasseurJ M Ruysschaert

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Citations

Sep 22, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gerald T AnkleyDaniel L Villeneuve
Mar 1, 1991·The Journal of Pharmacy and Pharmacology·R BrasseurH Vanden Bossche
Jun 1, 1986·Antimicrobial Agents and Chemotherapy·E L TolmanH Van den Bossche
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·N H GeorgopapadakouP T Funke
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·A M Sugar
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Robert S LiaoJames A Talbot
Jan 1, 2013·ISRN Preventive Medicine·M Anaul Kabir, Zulfiqar Ahmad
Jan 24, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Daniel L VilleneuveGerald T Ankley
Jul 1, 1984·Chemico-biological Interactions·R Arndt, J Ahlers
Feb 27, 2003·Journal of Veterinary Pharmacology and Therapeutics·H Vanden BosscheF Rochette
Jan 20, 2006·Pharmaceutical Research·Aristides DokoumetzidisPanos Macheras
Jan 24, 1983·The American Journal of Medicine·M BorgersM De Brabander
May 14, 1986·Biochemical and Biophysical Research Communications·D H BeachG G Holz
Oct 1, 1983·The Journal of Pharmacy and Pharmacology·R Arndt, B Schulz-Harder
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gerald T AnkleyVickie S Wilson
Jan 1, 1987·Critical Reviews in Microbiology·R O NicholasF J Wayman
Sep 15, 2019·Molecular Diversity·Jyoti Sankar Prusty, Awanish Kumar
Jun 19, 2007·Environmental Toxicology and Chemistry·Gerald T AnkleyDaniel L Villeneuve
Apr 1, 1985·Biochemical Pharmacology·J I MasonJ J Sheets

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