The interaction of phospholipid liposomes with bacteria and their use in the delivery of bactericides

Journal of Drug Targeting
M N JonesM D Reboiras

Abstract

Liposomes have been prepared from dipalmitoylphosphatidylcholine (DPPC) incorporating the cationic lipids stearylamine (SA), dimethyldioctadecylammonium bromide (DDAB) and dimethylaminoethane carbamoyl cholesterol (DCchol) and the anionic lipids dipalmitoylphosphatidylglycerol (DPPG) and phosphatidylinositol (PI). Their adsorption to biofilms of skin-associated bacteria (Staphylococcus epidermidis and Proteus vulgaris) and oral bacteria (Streptococcus mutans and sanguis) has been investigated as a function of mole % cationic and anionic lipid. Targeting (adsorption) was most effective for the systems DPPC-chol-SA, DPPC-DPPG and DPPC-PI liposomes to S. epidermidis. The effect of extracellular mucopolysaccharide on targeting was investigated for S. epidermidis biofilms. It was found that targeting increased with the level of extracellular mucopolysaccharide for all liposome compositions studied. The delivery of the oil-soluble bactericide Triclosan and the water soluble bactericide chlorhexidine was studied for a number of liposomal compositions. Superior delivery of both bactericides relative to the free bactericide occurred for DPPC-chol-SA liposomes and for Triclosan delivery by DPPC-DPPG and DPPC-PI liposomes targeted to S. e...Continue Reading

References

Oct 19, 1979·Biochimica Et Biophysica Acta·F OlsonD Papahadjopoulos
Aug 30, 1991·Biochemical and Biophysical Research Communications·X Gao, L Huang
Jan 1, 1990·The Journal of Infectious Diseases·B F FarberA G Clogston
Jan 16, 1989·Biochimica Et Biophysica Acta·F J HutchinsonM N Jones
Dec 1, 1987·Infection and Immunity·G D ChristensenW A Simpson
Jul 11, 1985·Biochimica Et Biophysica Acta·L D MayerA S Janoff
Jul 1, 1982·Infection and Immunity·G D ChristensenE H Beachey
Jan 1, 1994·Journal of Drug Targeting·M N JonesJ E Creeth
Aug 1, 1994·Biochemical Society Transactions·Y H Song, M N Jones
Nov 23, 1994·Biochimica Et Biophysica Acta·M N JonesJ E Creeth
Jul 13, 1994·Biochimica Et Biophysica Acta·M N Jones, M Kaszuba
Oct 1, 1993·Infection and Immunity·M Deighton, R Borland
Jun 1, 1993·Journal of Biomedical Materials Research·C C VerheyenK de Groot
Apr 22, 1993·Biochimica Et Biophysica Acta·M N JonesI G Lyle

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Citations

Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hassan LboutounneFabrice Pirot
Apr 25, 2003·International Journal of Pharmaceutics·Christelle Catuogno, Malcolm N Jones
Apr 20, 2000·Journal of Clinical Pharmacy and Therapeutics·S P VyasV Mishra
May 30, 2006·The Journal of Parasitology·Noritaka KubokiChihiro Sugimoto
Aug 16, 2013·International Journal of Nanomedicine·Ramanathan K KasimanickamJohn P Kastelic
Feb 2, 2013·International Journal of Pharmaceutical Investigation·Mohammad TariqJasjeet K Sahni
Jul 9, 2013·International Journal of Pharmaceutics·Ibrahim S I Al-AdhamPhillip J Collier
Jan 10, 2003·Journal of Liposome Research·Khalid AhmedMalcolm N Jones
Jul 12, 2003·Journal of Liposome Research·Khalid Ahmed, Malcolm N Jones
Jul 15, 2015·Journal of Liposome Research·Marika SuganoMatsuo Yamamoto
Jan 11, 2014·Drug Development and Industrial Pharmacy·Niloofar Moghadas-SharifBizhan Malaekeh-Nikouei
May 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Katrien ForierKevin Braeckmans
Feb 9, 2016·Microbial Pathogenesis·Bibi Sedigheh Fazly BazzazShiva Golmohammadzadeh
Apr 3, 2010·Chemistry and Physics of Lipids·Ivana KomljenovićEdward Sternin
Sep 16, 2008·Drug Discovery Today·Nilu JainRoop K Khar
Mar 18, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shunmugaperumal TamilvananAnnick Ludwig
Sep 26, 2006·International Journal of Pharmaceutics·S P VyasSanyog Jain
Aug 26, 2006·Colloids and Surfaces. B, Biointerfaces·Jin-Chul KimSang Moo Kim
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhengwei MaoJiacong Shen
Jun 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ilaria ColziSandra Ristori
May 28, 2016·Pharmaceutics·Zora Rukavina, Željka Vanić
Aug 17, 2000·Journal of Applied Microbiology·I S Al-AdhamP J Collier
Oct 13, 2012·International Journal of Immunopathology and Pharmacology·G Di TuriU Covani
Mar 3, 2021·Journal of Applied Microbiology·Yi Wang
May 23, 2001·Archives of Biochemistry and Biophysics·J VillalaínV Micol
Jun 6, 2021·International Journal of Pharmaceutics·Li DingZhengrong Cui

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