The interaction of prostaglandin E1 with serum lipoproteins. Possible role in cholesterol homeostasis

Lipids
L D Bergelson

Abstract

Prostaglandin (PG) E1 significantly stimulates the rate of cholesterol esterification in plasma. This effect could be attributed to an enhancement by PGE1 of the interlipoprotein transfer of phosphatidylcholine and cholesteryl esters, i.e., the substrate and product of lecithin-cholesterol acyltransferase (LCAT). The enhancement effect appears to be due to a rearrangement of the lipoprotein surface induced by specific interaction of PGE1 with some apolipoproteins, although the binding capacity of serum lipoproteins for PGE1 was found to be rather weak. To explain these findings, an hypothetical non-equilibrium model was put forward. The purpose of the present article is to summarize available data on the PGE1-lipoprotein interaction.

References

Jan 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S J Kirtland
Nov 25, 1988·Biochimica Et Biophysica Acta·E M ManevichL D Bergelson
Jun 12, 1987·Deutsche medizinische Wochenschrift·G TrübesteinS Horsch
May 2, 1988·European Journal of Biochemistry·V A SlepushkinL D Bergelson
Aug 1, 1985·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·P J Dolphin
May 1, 1985·Chemistry and Physics of Lipids·L D BergelsonY M Manevich
Aug 6, 1984·FEBS Letters·E M ManevichL D Bergelson

❮ Previous
Next ❯

Citations

Jan 1, 1995·Molecular Membrane Biology·L D Bergelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.