The interaction of SARS-CoV-2 and other coronavirus with Angiotensin Converting Enzyme 2 (ACE2) as their main receptor: therapeutic implications

Hypertension
Anne M DavidsonDaniel Batlle

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) originated from Wuhan, China in December 2019, and rapidly spread to other areas worldwide. Since then, COVID-19 has reached pandemic proportions with more than 570,000 deaths globally by mid-July 2020. The magnitude of the outbreak and the potentially severe clinical course of COVID-19 has led to a burst of scientific research on this novel coronavirus and its host receptor, angiotensin converting enzyme-2 (ACE2). ACE2 is a homolog of the angiotensin-I converting enzyme (ACE) that acts on several substrates in the renin-angiotensin system. With unprecedented speed, scientific research has solved the structure of SARS-CoV-2 and imaged its binding with the ACE2 receptor. In SARS-CoV-2 infection, the viral spike (S) protein receptor binding domain (RBD) binds to ACE2 to enter the host cell. ACE2 expression in the lungs is relatively low, but it is present in type II pneumocytes, a cell type also endowed with transmembrane protease serine 2 (TMPRSS2). This protease is critical for priming the SARS-CoV-2 S protein to complex with ACE2 and enter the cells. Herein, we review the current understanding of the interaction of SARS-CoV-2 with ACE2 as it has rapidly unfolded over...Continue Reading

References

Jun 21, 2002·Nature·Michael A CrackowerJosef M Penninger
Mar 8, 2003·Hypertension·Christos TikellisMark E Cooper
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Louise M BurrellMark E Cooper
May 29, 2004·Trends in Pharmacological Sciences·Anthony J TurnerNigel M Hooper
Jun 29, 2006·Diabetes·Jan WysockiDaniel Batlle
Dec 15, 2006·Nature·Ursula DanilczykJosef M Penninger
Jun 15, 2007·Cellular and Molecular Life Sciences : CMLS·Y ImaiJ M Penninger
Nov 14, 2008·American Journal of Physiology. Renal Physiology·María José SolerDaniel Batlle
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Jul 22, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Amal M El-ShehabyAmin R Roshdy
Nov 4, 2010·Current Opinion in Nephrology and Hypertension·Carlos M Ferrario
Jan 19, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Keiji KubaJosef M Penninger
Jun 14, 2013·American Journal of Physiology. Renal Physiology·Jan WysockiDaniel Batlle
Nov 13, 2013·Nature Reviews. Microbiology·Rachel L GrahamRalph S Baric
Apr 25, 2014·Current Hypertension Reports·Gisele Maia EtelvinoRobson Augusto Souza Santos
Mar 6, 2015·American Journal of Physiology. Cell Physiology·Nadja GrobeKhalid M Elased
Sep 1, 2015·Journal of Cardiovascular Pharmacology·Colleen T Cole-JeffreyVinayak Shenoy
Sep 1, 2016·Annual Review of Virology·Fang Li
Oct 8, 2016·Advances in Virus Research·R J G HulswitB-J Bosch
Sep 8, 2017·Critical Care : the Official Journal of the Critical Care Forum·Akram KhanAili L Lazaar
Sep 25, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chhinder P SodhiHongpeng Jia
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Robson Augusto Souza SantosMichael Bader

❮ Previous
Next ❯

Citations

Nov 3, 2020·Clinical Science·Enrique LoresDaniel Batlle
Nov 11, 2020·Lung·Filippo ScialoAndrea Bianco
Jan 12, 2021·Reviews in Medical Virology·Mohammad Mahmudur RahmanAsif Ahmed
Feb 3, 2021·Journal of the American Society of Nephrology : JASN·Jan WysockiDaniel Batlle
Feb 23, 2021·Reviews in Endocrine & Metabolic Disorders·Giovanni CoronaMario Maggi
Nov 18, 2020·American Journal of Hypertension·Marina RiederAchim Lother
Nov 6, 2020·American Journal of Hypertension·Ulrich O Wenzel, Ulrich Kintscher
Jan 28, 2021·American Journal of Physiology. Cell Physiology·Sudarshan KrishnamurthyNarasaiah Kolliputi
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Johanna Hol FosseReidunn Edelmann
Mar 23, 2021·International Journal of Peptide Research and Therapeutics·M A SiddiqaM V R Rao
Dec 10, 2020·American Journal of Respiratory Cell and Molecular Biology·Hongpeng JiaHonggang Cui
Mar 31, 2021·Molecular and Cellular Endocrinology·Nihal KaplanRobert M Lavker
Apr 6, 2021·Clinical Kidney Journal·María José Soler, Daniel Batlle
May 3, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sabrina Samad ShoilyAbu Ashfaqur Sajib
May 29, 2021·Frontiers in Immunology·Pankaj AhluwaliaRavindra Kolhe
Jun 24, 2021·Journal of Cellular and Molecular Medicine·Elham KarimiPegah Mousavi
Jul 6, 2021·Frontiers in Neuroscience·Allan GiriIsaac Kirubakaran Sundar
Jun 29, 2021·Frontiers in Cardiovascular Medicine·Somasundaram RaghavanM Dennis Leo
Jul 3, 2021·Sensors·Reena Sri SelvarajanAzrul Azlan Hamzah

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT00886353

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

BioRxiv : the Preprint Server for Biology
J. L. GanVaughn V. Smider
BioRxiv : the Preprint Server for Biology
Jessie Low-GanVaughn Smider
Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Yanwei LiRan You
Frontiers in Molecular Biosciences
Federica SaponaroRiccardo Zucchi
© 2021 Meta ULC. All rights reserved