PMID: 7831098Dec 1, 1994

The interaction of Trypanosoma congolense with endothelial cells

Parasitology
A HemphillC A Ross

Abstract

Factors which affect adhesion of cultured Trypanosoma congolense bloodstream forms to mammalian feeder cells have been examined. Using an in vitro binding assay, the initial events following interaction of trypanosomes with bovine aorta endothelial (BAE) cells were monitored by both light- and electron microscopy. Metabolic inhibitors and other biochemicals were incubated with either cells or parasites, to test whether any inhibited the process. Our findings suggest that adhesion of the parasites is an active process requiring metabolic energy from the trypanosomes, but not from endothelial cells. We also provide data suggesting that T. congolense bloodstream forms possess a lectin-like domain, localized at distinct sites on their flagellar surface, which interacts with specific carbohydrate receptors, most likely sialic acid residues, on the endothelial cell plasma membrane. We also suggest that the cytoskeletal protein actin is probably involved in this interaction.

References

Feb 1, 1979·The Journal of protozoology·K L Banks
May 1, 1978·The Journal of protozoology·K L Banks
Jan 1, 1991·Experimental Parasitology·S SchenkmanV Nussenzweig
Jan 1, 1991·Infection·J E Fowler
Jan 1, 1991·Nursing Forum·D RajacichM Foster
Apr 8, 1985·Journal of Immunological Methods·M P WoodwardR A Bloodgood
Feb 1, 1989·Current Opinion in Cell Biology·B Geiger
Oct 1, 1987·The Journal of Cell Biology·J A Cooper
May 1, 1988·Molecular and Cellular Biology·M F Ben AmarE Pays
Jan 1, 1985·Annual Review of Microbiology·J C Boothroyd
Apr 1, 1985·British Medical Bulletin·K Vickerman
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·G J LososF K Dar
Aug 1, 1974·Experimental Parasitology·B WelldeG Warui
Feb 1, 1969·The Journal of protozoology·K Vickerman
Feb 1, 1970·The Journal of protozoology·E Angelopoulos
Feb 1, 1980·European Journal of Biochemistry·M MonsignyF Delmotte
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K E NorgardN M Varki
Feb 1, 1990·Parasitology Today·T SeebackD Lawson

Citations

Feb 1, 1996·Parasitology·A HemphillH Kaufmann
Mar 9, 2010·PLoS Neglected Tropical Diseases·Virginie CoustouThéo Baltz
Nov 26, 2004·The Journal of Parasitology·Dennis J GrabKwang Sik Kim
Feb 1, 1996·Tropical Animal Health and Production·R BoidA G Luckins
Mar 8, 2005·The Journal of Veterinary Medical Science·Waren N BaticadosChihiro Sugimoto
Oct 11, 2016·Parasitology·Federica GiordaniMichael P Barrett
May 16, 2019·Open Biology·Sara Silva PereiraLuisa M Figueiredo

Related Concepts

Antimetabolites
Bos indicus
Cattle Diseases
Cell Adhesion
Endothelium, Vascular
Flagella
Electron Microscopy
Trypanosoma congolense
Nagana

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