PMID: 6106616Aug 1, 1980Paper

The interaction of vasoactive intestinal polypeptide (VIP), glucose and arginine on the secretion of insulin, glucagon and somatostatin in the perfused rat pancreas

Diabetologia
J SzecówkaS Efendić

Abstract

Vasoactive Intestinal Polypeptide (VIP) increased the release of insulin, glucagon and somatostatin from the perfused rat pancreas. The amount of these hormones released was dependent upon the prevailing glucose concentration. VIP stimulated glucagon release in the absence of glucose, while insulin and somatostatin release were increased by VIP only in the presence of glucose concentrations of 4.4 mmol/l and above. Glucagon secretion stimulated by arginine in the presence of 4.4 mmol/l glucose was potentiated by VIP. In contrast, VIP did not induce any further increase in the secretion of insulin and somatostatin over that stimulated by arginine. At higher concentrations of glucose (6.7, 16.7, and 33.3 mmol/l) VIP continued to stimulate insulin and somatostatin release, this effect being synergistic on early-phase insulin release. The effects of VIP on islet cells thus depend on the levels of modulating nutrients.

References

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Citations

Jan 1, 1989·Pharmacology & Therapeutics·J Fahrenkrug
Oct 1, 1983·Journal of the Autonomic Nervous System·P H Smith, B J Davis
Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H HorieS Tarui
Jan 1, 1982·Acta histochemica·A DornM Ziegler
Jul 6, 2000·Peptides·S Persson-SjögrenI B Täljedal
Feb 1, 1987·The Proceedings of the Nutrition Society·D R Matthews, A Clark
Feb 1, 1996·British Journal of Pharmacology·G BertrandM M Loubatières-Mariani
May 23, 2013·Pharmacology & Therapeutics·Stefan AmistenShanta J Persaud
Mar 3, 2012·Digestive Diseases and Sciences·M SasikalaD Nageshwar Reddy
Jan 1, 1988·Annals of the New York Academy of Sciences·N YanaiharaK Iguchi
Nov 1, 1982·The American Journal of Physiology·P Ronner, A Scarpa
Dec 1, 1982·The American Journal of Physiology·K V Axen, F X Pi-Sunyer
Oct 1, 1983·The American Journal of Physiology·J SzecówkaS Efendić
May 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·H C FehmannR Arnold

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