The interactions between cGAS-STING pathway and pathogens.

Signal Transduction and Targeted Therapy
Zhangliang ChengFangfang Zhou

Abstract

Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) detects DNA and then mediates downstream immune responses through the molecule stimulator of interferon genes (STING, also known as MITA, MPYS, ERIS and TMEM173). Recent studies focusing on the roles of the cGAS-STING pathway in evolutionary distant species have partly sketched how the mammalian cGAS-STING pathways are shaped and have revealed its evolutionarily conserved mechanism in combating pathogens. Both this pathway and pathogens have developed sophisticated strategies to counteract each other for their survival. Here, we summarise current knowledge on the interactions between the cGAS-STING pathway and pathogens from both evolutionary and mechanistic perspectives. Deeper insight into these interactions might enable us to clarify the pathogenesis of certain infectious diseases and better harness the cGAS-STING pathway for antimicrobial methods.

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Citations

Sep 10, 2020·Viruses·Tongtong Zhu, Ana Fernandez-Sesma
Jan 10, 2021·International Journal of Molecular Sciences·Guendalina FroechlichNicola Zambrano
Feb 27, 2021·Frontiers in Immunology·Haruna OkudeTaro Kawai
Mar 12, 2021·BMC Biotechnology·Cynthia AslanReza Jafari
May 23, 2021·Reviews in Medical Virology·Forough Golsaz-Shirazi, Fazel Shokri
Jun 4, 2021·Proceedings of the National Academy of Sciences of the United States of America·Fumi Sato-KanekoDennis A Carson
Jun 4, 2021·Signal Transduction and Targeted Therapy·Ruoxi ZhangDaolin Tang
Jun 6, 2021·Nature Reviews. Molecular Cell Biology·Ning Jia, Dinshaw J Patel
Aug 7, 2021·Molecular Aspects of Medicine·Jiarong ZhouLiangfang Zhang
Nov 1, 2021·Journal of Molecular Cell Biology·Yongai XiongChunfu Zheng
Dec 16, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinxin KeMizu Jiang

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Methods Mentioned

BETA
lipidation
sumoylation
acetylation
ubiquitination
nuclear translocation

Software Mentioned

cGAS
mSTING
STING
hSTING

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