The Interactions between HBV and the Innate Immunity of Hepatocytes.

Viruses
Fayed Attia Koutb MegahedPingnan Sun

Abstract

Hepatitis B virus (HBV) infection affects ~350 million people and poses a major public health problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer than 5% of HBV-infected adults (but up to 90% of HBV-infected infants and children) develop chronic HBV infection as indicated by continued, detectable expression of hepatitis B surface antigen (HBsAg) for at least 6 months after the initial infection. Increasing evidence indicates that HBV interacts with innate immunity signaling pathways of hepatocytes to suppress innate immunity. However, it is still not clear how HBV avoids monitoring by the innate immunity of hepatocytes and whether the innate immunity of hepatocytes can be effective against HBV if re-triggered. Moreover, a deep understanding of virus-host interactions is important in developing new therapeutic strategies for the treatment of HBV infection. In this review, we summarize the current knowledge regarding how HBV represses innate immune recognition, as well as recent progress with respect to in vitro models for studying HBV infection and innate immunity.

References

Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H MillerR H Purcell
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S TwuR H Schloemer
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M A SellsG Acs
Jun 4, 1999·The Journal of General Virology·O RosmorducD Kremsdorf
Jan 5, 2000·The Journal of Clinical Investigation·P SoussanD Kremsdorf
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Philippe GriponChristiane Guguen-Guillouzo
May 24, 2003·Journal of Hepatology·Henning Schulze-BergkamenUlrike Protzer
Apr 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stefan WielandFrancis V Chisari
Sep 11, 2004·Biochemical and Biophysical Research Communications·Yakov FelligMali Ketzinel-Gilad
Nov 17, 2004·Current Drug Metabolism·M J Gómez-LechónR Jover
Oct 27, 2005·International Journal of Epidemiology·Susan T GoldsteinHarold S Margolis
Oct 27, 2006·Journal of Virology·Verena ChristenMarkus H Heim
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kumar VisvanathanStephen Locarnini
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·David C HayJohn P Iredale
Jan 6, 2009·Immunological Reviews·Osamu Takeuchi, Shizuo Akira
Aug 5, 2009·The Journal of Experimental Medicine·Sarah M McWhirterRussell E Vance
Oct 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gareth J SullivanIan Wilmut
Nov 17, 2009·Journal of Hepatology·Laurent DolléAlbert Geerts
Nov 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianna HöselUlrike Protzer
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Congwen WeiHui Zhong
Sep 18, 2010·Mediators of Inflammation·Aswin HariP Régine Mydlarski
Apr 15, 2011·Genes and Immunity·S NingG N Barber
Sep 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andreas SchulzeStephan Urban
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert E SchwartzSangeeta N Bhatia
May 4, 2012·Oncology Reports·Li ChenYuan-Yuan Zhu
May 24, 2012·Journal of Hepatology·Xiaoyong ZhangMengji Lu
Jul 21, 2012·Seminars in Immunopathology·Qiuju HanZhigang Tian
Sep 22, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jieliang ChenZhenghong Yuan

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Citations

Dec 11, 2020·Antiviral Research·Paul T WinnardVenu Raman
Feb 17, 2021·Nature Reviews. Gastroenterology & Hepatology·Jordi Gracia-SanchoRubén Francés
Mar 17, 2021·Phytotherapy Research : PTR·Yijia ZengJilin Sun
Apr 4, 2021·Life·Srikanth Elesela, Nicholas W Lukacs
May 23, 2021·Reviews in Medical Virology·Forough Golsaz-Shirazi, Fazel Shokri
Jun 18, 2021·Seminars in Liver Disease·David A Kukla, Salman R Khetani
Aug 14, 2021·Frontiers in Cell and Developmental Biology·Zhilei WangZhaofang Bai
Aug 28, 2021·Cells·Maximilian HirschenbergerKonstantin Maria Johannes Sparrer
Sep 15, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Marion DelphinSuzanne Faure-Dupuy

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Methods Mentioned

BETA
nuclear translocation
ubiquitination
biopsies
transfection
gene knockout

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