PMID: 22553779May 4, 2012Paper

The interactions of therapeutic antibodies with Fc receptors

Immunology Letters
Marcello Albanesi, Marc Daëron

Abstract

During the last two decades, a rapidly increasing number of therapeutic antibodies have been generated and used in a variety of diseases. The rationale of passive immunotherapy is that, due to their unique specificity, antibodies can selectively target and act on molecules associated with pathological processes. However, how therapeutic antibodies actually act on target molecules and cells under specific conditions is poorly known. As a consequence, whether the efficacy of available antibodies could be increased and whether new antibodies could be tailored for specific purposes have not been thoroughly investigated. We discuss in this review how therapeutic antibodies interact with Fc receptors, what are the cellular responses induced by these interactions and how a better knowledge of these interactions and biological responses could improve antibody-based passive immunotherapy.

References

Jan 1, 1991·Annual Review of Immunology·J V Ravetch, J P Kinet
Jul 1, 1990·The Journal of Experimental Medicine·P A WarmerdamP J Capel
May 1, 1989·The Journal of Clinical Investigation·P A OryS B Clarkson
Mar 30, 1989·Nature·M Reth
Feb 1, 1995·The Journal of Clinical Investigation·M DaëronW H Fridman
Nov 24, 1994·Nature·W P BurmeisterP J Bjorkman
Mar 22, 1996·Science·D R LeachJ P Allison
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R P Junghans, C L Anderson
Jan 1, 1997·Annual Review of Immunology·M Daëron
Mar 31, 2000·Nature Medicine·R A ClynesJ V Ravetch
Feb 7, 2001·Cancer Immunology, Immunotherapy : CII·D ShanO W Press
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·W BusseN Gupta
Jul 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola Di GaetanoJosée Golay
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam D KennedyRonald P Taylor
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P TreonEdward A Fox
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Renaud LesourneMarc Daëron
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rinpei NiwaKenya Shitara
Sep 17, 2005·The Journal of Clinical Investigation·Adam M BoruchovJames W Young
Feb 9, 2006·Current Opinion in Immunology·Karl S PeggsJames P Allison
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Tse Wen Chang, Yu-Yu Shiung
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei ZhaoLawrence B Schwartz
Jun 24, 2006·The Journal of Biological Chemistry·William F Dall'AcquaHerren Wu
Oct 13, 2006·Annual Review of Immunology·James N ArnoldRaymond A Dwek
Mar 3, 2007·Cancer Research·Jérôme GalonFranck Pagès
Mar 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonino MusolinoAndrea Ardizzoni
May 13, 2008·Nature Reviews. Cancer·Klaus Strebhardt, Axel Ullrich
Jul 4, 2008·Nature Reviews. Cancer·Lee M Ellis, Daniel J Hicklin
Sep 2, 2008·Immunological Reviews·Marc DaëronEric Vivier
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle A OttenMarjolein van Egmond
Jan 7, 2009·Current Opinion in Oncology·Oliver KeppGuido Kroemer
Feb 3, 2009·British Journal of Haematology·John G Gribben, Michael Hallek
May 12, 2009·Immunological Reviews·Raul ElguetaRandolph J Noelle

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Citations

Nov 12, 2013·BMC Veterinary Research·David P GearingAlexander C Drew
Apr 16, 2015·MAbs·Céline RaymondYves Durocher
Oct 27, 2015·Immunological Reviews·Jose M M CaaveiroKouhei Tsumoto
Dec 16, 2016·Expert Opinion on Biological Therapy·Jogender Tushir-Singh
Feb 11, 2018·Scientific Reports·Hirokazu YagiKoichi Kato
Jan 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathilde BasCéline Monnet
Jul 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dandan PengGuangchang Pang
Apr 30, 2014·International Journal of Immunopathology and Pharmacology·A ArmuzziR Cimaz
Jul 8, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruce D WinesP Mark Hogarth

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