The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young women.

Psychoneuroendocrinology
Michael C CraigDeclan G M Murphy

Abstract

Women have an increased risk of developing Alzheimer's Dementia (AD) compared to men. It has been postulated that this risk may be modulated by a reduction in the neuroprotective effects of estrogen on the brain in the early postmenopausal period. This view is supported by, for example, findings that ovariectomy in younger women (i.e. prior to menopause) significantly increases the risk for the development of memory problems and AD in later life. However, the biological basis underlying these cognitive changes is still poorly understood. Our aim in the current study was to understand the interactive effects of acute, pharmacological-induced menopause (after Gonadotropin Hormone Releasing Hormone agonist (GnRHa) treatment) and scopolamine (a cholinergic antagonist used to model the memory decline associated with aging and AD) on brain functioning. To this end we used fMRI to study encoding during a Delayed Match to Sample (DMTS) (visual working memory) task. We report a relative attenuation in BOLD response brought about by scopolamine in regions that included bilateral prefrontal cortex and the left parahippocampal gyrus. Further, this was greater in women post-GnRHa than in women whose ovaries were functional. Our results also...Continue Reading

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Citations

Jan 4, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Michael C Craig
Jul 10, 2010·Menopause : the Journal of the North American Menopause Society·Julie A DumasPaul A Newhouse
Jun 29, 2011·Progress in Neurobiology·Paul BentleyRaymond J Dolan
Aug 23, 2011·Neurobiology of Aging·Laura D BakerSuzanne Craft
Dec 30, 2014·Frontiers in Neuroscience·Erika ComascoInger Sundström-Poromaa
Dec 17, 2014·Metabolic Brain Disease·K V Simonyan, V A Chavushyan
May 27, 2021·Scientific Reports·Gergely SomogyiAndrás Czurkó

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