The intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism is not associated with ischaemic heart disease: an investigation using family-based tests of association

European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics
Paul G McGlincheyPascal P McKeown

Abstract

The possible role of the K469E polymorphism in the intercellular adhesion molecule-1 (ICAM-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family-based tests of association. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped for the ICAM-1 K469E polymorphism. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the ICAM-1 K469E polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the ICAM-1 K469E polymorphism is not associated with IHD.

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Citations

Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tarek MotawiMarwa Abdel Raheem
Jul 4, 2015·Indian Heart Journal·C AnbarasanS Ajit Mullasari
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Syed Douhath YousufFouzia Rashid
Aug 10, 2020·Journal of Cellular and Molecular Medicine·Cungang Wu, Chao Huang

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