The interdependent roles of Ca(2+) and cAMP in axon guidance

Developmental Neurobiology
Daniel J Sutherland, Geoffrey J Goodhill

Abstract

Axon guidance is a fundamental process in the developing and regenerating nervous system that is necessary for accurate neuronal wiring and proper brain function. Two of the most important second messengers in axon guidance are Ca(2+) and cAMP. Recently experimental and theoretical studies have uncovered a Ca(2+) - and cAMP-dependent mechanism for switching between attraction and repulsion. Here, we review this process and related Ca(2+) and cAMP interactions, the mechanisms by which necessary intracellular calcium elevations are created, and the pathways, which effect attractive and repulsive responses to the switch.

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Citations

Feb 5, 2015·Developmental Neurobiology·Hiroyuki Kamiguchi, Laura N Borodinsky
Sep 8, 2017·Journal of Biomedical Materials Research. Part a·Agnese GugliandoloEmanuela Mazzon
Aug 14, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Michihiro Igarashi

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Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.