The interference of nitro- and polycyclic musks with endogenous and xenobiotic metabolizing enzymes in carp: an in vitro study

Environmental Science & Technology
Sabine SchnellCinta Porte

Abstract

Synthetic musks are widely used as perfuming agents in products, such as cosmetics, detergents, and soaps. The increased detection of these substances in the aquatic environment and their high bioconcentration potential raises concerns about potential effects on aquatic species. This work aimed at assessing the interactions of the most widely used musks: nitromusks (musk xylene, musk ketone) and polycyclic musks (celestolide, galaxolide, and tonalide) with fish enzymatic systems involved in both xenobiotic and endogenous metabolism. Therefore, CYP catalyzed pathways were investigated in carp liver microsomes (CYP1A, CYP3A), ovarian microsomes (CYP19) and testicular mitochondria (CYP17 and CYP11beta) using standard substrates. Phase II activities (UDP-glucuronosyltransferases and sulfotransferases) were determined in carp liver microsomes and cytosol, respectively. Polycyclic musks (galaxolide and tonalide) were stronger inhibitors of CYP3A- (IC(50): 68-74 microM), CYP17- (IC(50): 213-225 microM), CYP11beta- and CYP19-catalyzed activities than nitromusks, while the latter showed higher ability to interfere with CYP1A (IC(50): 35-37 microM). The sulfation of estradiol was also significantly inhibited by tonalide and galoxolide (I...Continue Reading

References

Apr 1, 1992·Biochemical Pharmacology·D Zakim, A J Dannenberg
Jan 1, 1983·Archives of Environmental Contamination and Toxicology·T YamagishiK Akiyama
Apr 22, 1993·Biochemical Pharmacology·N IwataA Takahashi
Sep 23, 1996·Mutation Research·V Mersch-SundermannA Reinhardt
Jan 1, 1997·Toxicology and Applied Pharmacology·L D Lehman-McKeemanD Caudill
Mar 14, 1998·Toxicology and Applied Pharmacology·C L MirandaD R Buhler
Dec 11, 1999·Environmental Health Perspectives·C G Daughton, T A Ternes
Jan 12, 2000·Toxicology Letters·G G Rimkus
May 19, 2000·Toxicology Letters·R Suter-EichenbergerM Schlumpf
Jul 4, 2001·International Journal of Hygiene and Environmental Health·H H SchmeiserV Mersch-Sundermann
Jul 13, 2001·Mutation Research·V Mersch-SundermannS Knasmüller
Sep 1, 2001·Journal of Environmental Monitoring : JEM·R KallenbornG G Rimkus
Jan 31, 2004·Environmental Science & Technology·Aaron M Peck, Keri C Hornbuckle
Mar 5, 2004·Environmental Science & Technology·Richard H M M SchreursBart Van der Burg
Apr 15, 2004·Toxicology and Applied Pharmacology·Ramón LavadoCinta Porte
Feb 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Rémi Thibaut, Cinta Porte
Aug 23, 2005·Marine Pollution Bulletin·Shinsuke Tanabe
Apr 19, 2007·Environmental Science & Technology·Haruhiko NakataKurunthachalam Kannan

❮ Previous
Next ❯

Citations

Mar 13, 2014·Environmental Health : a Global Access Science Source·Kathryn M TaylorJames Shine
Aug 5, 2014·Aquatic Toxicology·Denise FernandesCinta Porte
Jan 31, 2015·International Journal of Environmental Research and Public Health·Matthew O GribbleMary A Fox
Sep 27, 2014·International Journal of Hygiene and Environmental Health·Xiaolan ZhangYingxin Yu
Apr 11, 2015·Environmental Science and Pollution Research International·Krisztina VinczeRita Triebskorn
Jun 22, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Elisa RandelliGiuseppe Scapigliati
Jun 8, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C Della TorreI Corsi
Feb 5, 2013·The Science of the Total Environment·Denise Fernandes, Cinta Porte
Aug 9, 2011·Marine Pollution Bulletin·Denise FernandesCinta Porte
May 22, 2016·Marine Pollution Bulletin·Elisabet Pérez-AlbaladejoCinta Porte
Nov 28, 2017·Archives of Environmental Contamination and Toxicology·Jana BlahovaZdenka Svobodova
Nov 21, 2020·Environmental Science and Pollution Research International·Yang LyuZhenwu Tang
Sep 17, 2014·Environmental Science & Technology·Carla Ribalta, Montserrat Solé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.