The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1

Gene
I StrehlowT Decker

Abstract

We have isolated DNA clones containing the interferon (IFN)-inducible guanylate-binding protein-1-encoding gene (GBP1) from a human genomic library. Two overlapping phage clones contained the entire GBP1 gene. The 2880 bp corresponding to the GBP1 cDNA were subdivided into eleven exons which were interrupted by a total of 9500 bp of intron DNA. All exon/intron junctions contained consensus splice donor and acceptor sequences. Using hybrid rodent cell lines containing human chromosomes, GBP1 was mapped to human chromosome 1. In addition to GBP1, we detected and partially characterized a novel gene, GBP3, with a structure related to GBP1 and a high degree of sequence homology to both GBP1 and GBP2. Our data suggest that the GBP family of genes contains members other than the previously characterized GBP1 and GBP2.

References

Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Aug 1, 1993·Trends in Cell Biology·P StaeheliJ Pavlovic

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Citations

Oct 22, 2002·FEBS Letters·Zhidong LuanGengxi Hu
Mar 1, 1997·Genetic Analysis : Biomolecular Engineering·N E Morton, A Collins
Oct 25, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tam Thuan NguyenJeffrey B Smith
Aug 20, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Deborah J Vestal
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Maureen A OlszewskiDeborah J Vestal
Jun 4, 2004·The Journal of Investigative Dermatology·Friederike FellenbergStefan Eichmüller
Mar 5, 2004·The British Journal of Dermatology·T B HartmannS Eichmüller

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