The interferon-tau genes of the giraffe, a nonbovid species.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
L LiuR M Roberts

Abstract

Genes for interferon-tau (IFNT) have been cloned from several Bovidae, and the IFNT lineage has been predicted to have arisen from the IFNW, as the divergence of the Ruminantia from other artiodactyls. Southern genomic blotting with probes specific for IFNT identified a gene in the giraffe, a nonbovid member of the Ruminantia. Here this gene has been cloned, sequenced, and expressed. It encodes a 172-amino acid mature protein with antiviral activity on bovine cells. Giraffe IFN-tau lacks the normally conserved Cys99 but has a pair of other cysteines (Cys64 and Cys86) that could provide a disulfide bridge. The giraffe IFNT gene possesses the highly conserved promoter region that distinguishes IFNT from IFNW. It seems likely that IFNT emerged before the divergence of the Giraffidae and Bovidae, which occurred some 24 million years ago.

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J C Cross, R M Roberts
Apr 1, 1989·Journal of Interferon Research·R M RobertsL H Kronenberg
Dec 1, 1986·Journal of Interferon Research·M W BeilharzA W Linnane
Dec 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T SendaR M Roberts

❮ Previous
Next ❯

Citations

Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·T EzashiR M Roberts
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A P AlexenkoR M Roberts
Mar 28, 2009·Theriogenology·Angela M WalkerR Michael Roberts
Oct 7, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Toshihiko Ezashi, Kazuhiko Imakawa
Jan 23, 1999·International Reviews of Immunology·E De Maeyer, J De Maeyer-Guignard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.