The interleukin-1 beta +3953 single nucleotide polymorphism: cervical protein concentration and preterm delivery risk

American Journal of Reproductive Immunology : AJRI
Rodney K EdwardsPatrick Duff

Abstract

To determine the associations between preterm delivery <37 weeks (PTD), cervical fluid interleukin-1beta (IL-1beta) concentration, and its +3953 single nucleotide polymorphism (SNP). Cervical fluid, peripheral blood, and cord blood samples were obtained from a cohort of women 23-32 weeks gestation with preterm labor symptoms and intact membranes. Increased cervical fluid concentrations of IL-1beta were associated with PTD (P = 0.017) and spontaneous PTD (P = 0.001). Maternal IL-1beta +3953 SNP genotype was associated neither with PTD (P = 0.43) nor with cervical fluid IL-1beta concentrations (P = 0.35). Neonatal IL-1beta +3953 SNP genotype was associated neither with PTD nor cervical IL-1beta concentrations. Cervical fluid concentrations of IL-1beta were elevated in symptomatic women destined to have a spontaneous PTD. The gene dosage of maternal IL-1beta +3953 allele 2 was associated neither with increased cervical fluid concentrations of IL-1beta nor with risk of PTD.

References

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Mar 5, 2005·American Journal of Obstetrics and Gynecology·Rodney K EdwardsPatrick Duff

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Citations

Dec 8, 2009·Archives of Gynecology and Obstetrics·Laura DonatiGiancarlo Paradisi
Jan 24, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Harald Leitich, Herbert Kiss
Jun 21, 2011·DNA and Cell Biology·Yaprak YılmazFatma Belgin Atac
Aug 14, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maximilian SchmidChristoph Grimm
Feb 11, 2014·Clinics in Chest Medicine·Peter J Barnes
May 11, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Nicolas M OrsiNigel A B Simpson
Jan 8, 2013·American Journal of Reproductive Immunology : AJRI·Adam BitnerJarosław Kalinka
Oct 18, 2016·Pharmacogenetics and Genomics·Immaculate M LangmiaZahurin Mohamed
Jan 27, 2019·Scientific Reports·Masao ShimaokaNoriomi Matsumura
Feb 8, 2021·Journal of Perinatal Medicine·Ana Paula V D AlvesMario Henrique B Carvalho

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