The interleukin 1beta gene promoter polymorphism (-511) acts as a risk factor for psychosis in Alzheimer's dementia

Annals of Neurology
D CraigA P Passmore

Abstract

The explanation for why some patients develop psychotic change in Alzheimer's disease (AD) is unclear. "Psychosis-modifier genes" may act in the setting of neurodegeneration to produce AD plus psychosis in a similar way to how genetic modulation during neurodevelopment leads to schizophrenia. Because there is increasing interest in the common disruption of cytokine pathways seen in both AD and schizophrenia, we tested the association between the functional interleukin-1beta -511 promoter polymorphism with delusions and hallucinations in AD. Significant associations between psychotic symptoms and the CC genotype (p = 0.001 - p = 0.043) and C allele (p = 0.014 vs p = 0.048) were found, thus confirming the previously noted increased risk in schizophrenia.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M Araujo, C W Cotman
Apr 20, 1999·Molecular Psychiatry·H KatilaM Hurme
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Marieke Wichers, Michael Maes
Dec 25, 2002·International Review of Neurobiology·Fiona Gaughran
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Franck SchürhoffMarion Leboyer
May 13, 2003·Molecular Psychiatry·R A SweetD V Jeste
Jun 6, 2003·Applied Neuropsychology·Konstantine K ZakzanisTaline Sethian
Aug 12, 2003·Brain Research Bulletin·Elisabeth TarkowskiKaj Blennow
Sep 27, 2003·Dementia and Geriatric Cognitive Disorders·Suk Ling MaHelen Fung Kum Chiu
Oct 18, 2003·Journal of Psychiatric Research·Roberta ZanardiniMassimo Gennarelli

❮ Previous
Next ❯

Citations

Sep 1, 2005·Current Neurology and Neuroscience Reports·Dag AarslandClive Ballard
Mar 16, 2011·Current Psychiatry Reports·Zahinoor IsmailDavid Mamo
Nov 16, 2007·Comprehensive Therapy·Hani Raoul Khouzam, Robert Emes
Oct 3, 2006·Current Opinion in Psychiatry·Thomas W MeeksDilip V Jeste
Mar 15, 2011·Alzheimer Disease and Associated Disorders·Edward C Lauterbach
Dec 23, 2011·International Journal of Alzheimer's Disease·Paolo OlgiatiAlessandro Serretti
Jun 3, 2014·Current Genetic Medicine Reports·Mary Ann A DeMichele-Sweet, Robert A Sweet
May 6, 2014·Maturitas·Andrew H Ford
Mar 8, 2016·Neural Plasticity·Jorge I VélezMauricio Arcos-Burgos
Aug 23, 2012·Neuroscience and Biobehavioral Reviews·Suzanne J ReevesRobert J Howard
Nov 13, 2004·Journal of Clinical Psychopharmacology·Theoharis C TheoharidesPio Conti
May 12, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·P HollingworthJ Williams
Jul 21, 2009·International Journal of Geriatric Psychiatry·Paolo OlgiatiAlessandro Serretti
Oct 20, 2010·International Journal of Geriatric Psychiatry·Paul HollingworthJulie Williams
Jul 1, 2020·Dementia and Neurocognitive Disorders·YoungSoon YangYong Tae Kwak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.