The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype

Annals of the Rheumatic Diseases
Blanca RuedaT R D J Radstake

Abstract

Multiple studies indicate the role of the interleukin (IL)-17/IL-23 axis in autoimmune diseases, including systemic sclerosis (SSc). The aim of the current study was to investigate the possible implication of the IL23R gene in SSc susceptibility and/or clinical phenotype. An initial case-control study in 143 Dutch patients with SSc and geographically matched healthy individuals (n = 246) was carried out and followed by a replication study in a cohort of 365 Spanish patients with SSc and 515 healthy individuals. Seven single nucleotide polymorphisms (SNPs) spanning the IL23R gene were selected and genotyped using a Taqman assay. Using a Dutch cohort of patients with SSc and controls we observed an association between two (rs11209032, rs1495965) of the seven tested SNPs and disease susceptibility (allelic p values: p = 0.02 and p = 0.01 respectively). However, a replication study in an independent Spanish cohort did not confirm these findings and reveal no association of any of the IL23R-tested SNP with disease susceptibility or clinical phenotype. Similarly, a meta-analysis considering both populations did not reveal any significant association. In addition, no association was observed between IL23R genetic variants and SSc clin...Continue Reading

Citations

Sep 17, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Eniko SafranyBela Melegh
Jun 12, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Gui-Mei ChenDong-Qing Ye
Jan 22, 2010·Current Opinion in Rheumatology·Sandeep K Agarwal, John D Reveille
Jan 1, 2011·Archivos de bronconeumología·Julio Sánchez RománRocío González León
Mar 23, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniela FenoglioGilberto Filaci
Sep 21, 2010·La Revue de médecine interne·S TradZ Amoura
Sep 6, 2012·European Journal of Immunology·Aurélie AmbrosiMarie Wahren-Herlenius
Jan 29, 2014·International Journal of Rheumatic Diseases·Anna Olewicz-GawlikPawel Hrycaj
Jun 25, 2015·Frontiers in Immunology·Debendra PattanaikArnold E Postlethwaite
Dec 20, 2017·Autoimmunity·Rafaela Silva Guimarães GonçalvesMaira Galdino R Pitta
Jan 1, 2015·Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine·Akiko TochimotoHisashi Yamanaka
Jul 28, 2011·Expert Review of Clinical Immunology·Jasper C A BroenTimothy R D J Radstake
Oct 21, 2014·The Open Rheumatology Journal·Jingxiao JinXiaodong Zhou
Sep 1, 2015·Current Opinion in Rheumatology·Paula S RamosCarol A Feghali-Bostwick
Sep 19, 2017·Immunology Letters·Carlo ChizzoliniNicolò Costantino Brembilla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.