The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Scientific Reports
Melanie L BuckleyDipak P Ramji

Abstract

Atherosclerosis, a chronic inflammatory disorder of the walls of arteries, causes more deaths worldwide than any other disease. Cytokines, which are present at high levels in atherosclerotic plaques, play important roles in regulating the initiation and the progression of the disease. Previous studies using animal and cell culture model systems revealed protective, anti-atherogenic effects of the cytokine interleukin-33 (IL-33). The action of this cytokine involves both the induction and suppression of expression of many genes. Unfortunately, the signaling pathways that are responsible for the inhibition of gene expression by this cytokine are poorly understood. Further studies are required given the important roles of genes whose expression is inhibited by IL-33 in key cellular processes associated with atherosclerosis such as monocyte recruitment, foam cell formation and lipoprotein metabolism. We have investigated here the roles of various known IL-33 activated signaling pathways in such inhibitory actions using RNA interference-mediated knockdown assays and monocyte chemotactic protein-1 and intercellular adhesion molecule-1 as model genes. Key roles were identified for extracellular signal-regulated kinase-1/2, p38α kinase...Continue Reading

References

Oct 29, 1999·DNA and Cell Biology·R A RippeD A Brenner
Jul 19, 2002·Cardiovascular Research·James R Mead, Dipak P Ramji
Apr 1, 2004·Molecular Cell·Kirsteen J CampbellNeil D Perkins
Apr 9, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pu QinDouglas C Harnish
Feb 13, 2008·The Journal of Experimental Medicine·Ashley M MillerFoo Y Liew
Jul 8, 2008·Cellular Signalling·Megumi Funakoshi-TagoTadashi Kasahara
Oct 2, 2008·Nature Reviews. Drug Discovery·Rahul Kakkar, Richard T Lee
Jan 15, 2009·Cellular Microbiology·Yen-Cheng LinLing-Pai Ting
Apr 14, 2010·The Journal of Biological Chemistry·Vaibhao C JanbandhuVijay Kumar
Jun 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·James E McLarenDipak P Ramji
Aug 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Na LiDipak P Ramji
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiko YagamiAkio Matsuda
Oct 14, 2010·Cellular Signalling·Megumi Funakoshi-TagoTadashi Kasahara
May 24, 2011·Progress in Lipid Research·James E McLarenDipak P Ramji
Jan 12, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R KamekuraT Himi
Nov 20, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Jürgen PollheimerJohanna Hol
Sep 3, 2013·Nature Reviews. Immunology·Kathryn J MooreEdward A Fisher
Mar 13, 2014·Journal of Cellular Biochemistry·Julia LeidnerRalf B Marienfeld
Nov 5, 2014·Proteomics·Sneha M PintoAkhilesh Pandey
May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Sep 30, 2015·Immunity, Inflammation and Disease·Praxedis MartinCem Gabay
Jul 1, 2016·Future Medicinal Chemistry·Joe We Moss, Dipak P Ramji
Jul 26, 2016·Frontiers in Cell and Developmental Biology·Marc K Saba-El-LeilSylvain Meloche

❮ Previous
Next ❯

Citations

Nov 8, 2019·Molecular Nutrition & Food Research·Victoria L O'Morain, Dipak P Ramji
Mar 17, 2020·Future Medicinal Chemistry·Yee-Hung Chan, Dipak P Ramji
May 5, 2020·Frontiers in Cellular and Infection Microbiology·Nathan RyanSteve Oghumu
Feb 2, 2021·Immunological Investigations·Faezeh RamezaniHamed Mohammadi
Feb 2, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Magy SallamAn Aerts
Nov 11, 2020·International Journal of Molecular Sciences·Carla DahlemChristoph F A Vogel
Sep 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wijdan Al-AhmadiDipak P Ramji

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
PCR
transfections
PMA

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

© 2021 Meta ULC. All rights reserved