The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Liesl de MilanderMalcolm Collins

Abstract

Previous studies have identified an association of genetic variants believed to alter physiological and biochemical processes locally within the skeletal muscle and therefore performance in the Ironman triathlon. There is growing evidence that the serotonergic system and circulating interleukin (IL)-6 levels are also involved in mediating endurance capacity. Investigators have demonstrated that recombinant human IL-6 administration and serotonergic neurotransmission manipulation, with 5-hydroxytryptamine transporter (5-HTT) and monoamine oxidase A (MAO-A) inhibitors, prior to exercise, can alter running performance, consistent with a central governor hypothesis. The aim of this study was to investigate possible associations of functional polymorphisms within the IL-6, 5-HTT, and MAO-A genes with endurance performance of Ironman triathletes. Four hundred sixty-eight male Caucasian triathletes who completed the 2000 and (or) 2001 South African Ironman Triathlon and 200 healthy Caucasian male controls were genotyped for the -174 IL-6 G/C, 5-HTT 40 base pair (bp) insertion-deletion and 30 bp variable number of tandem repeats (VNTR) MAO-A gene polymorphisms. There were no significant differences in the relative genotype distribution...Continue Reading

References

May 1, 1992·Acta Physiologica Scandinavica·S P BaileyE N Ahlborn
Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Oct 1, 1991·Acta Physiologica Scandinavica·E BlomstrandE A Newsholme
Aug 1, 1993·International Journal of Sports Medicine·S P BaileyE N Ahlborn
Jan 1, 1995·Advances in Experimental Medicine and Biology·E A Newsholme, E Blomstrand
Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Jan 1, 1997·Medicine and Science in Sports and Exercise·J M Davis, S P Bailey
Nov 3, 1998·Human Genetics·S Z SabolD Hamer
Nov 24, 1998·The Journal of Physiology·K OstrowskiB K Pedersen
Oct 12, 1999·Journal of Applied Physiology·S MyersonH Montgomery
Feb 29, 2000·Medicine and Science in Sports and Exercise·L L Smith
Jul 6, 2000·European Journal of Applied Physiology·R AlvarezE Coto
Feb 24, 2001·Pflügers Archiv : European journal of physiology·F E MarinoS C Dennis
Apr 20, 2001·Amino Acids·E Blomstrand
May 17, 2001·Human Genetics·D WoodsH Montgomery
Oct 16, 2001·The Journal of Physiology·B K PedersenP Schjerling
Aug 3, 2002·The Journal of Physiology·Lars NyboNiels H Secher
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa J SmithCynthia L Bethea
Aug 5, 2004·Medicine and Science in Sports and Exercise·Malcolm CollinsTimothy D Noakes
Aug 20, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Paula J Robson-AnsleyTimothy D Noakes
Nov 25, 2004·British Journal of Sports Medicine·K A SharwoodT D Noakes
Jul 23, 2005·International Journal of Sports Medicine·A LucíaC P Earnest
Jan 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Masaki MorishimaYutaka Nakaya
Apr 28, 2006·American Journal of Human Genetics·Xian-Zhang HuDavid Goldman
Nov 11, 2006·Medicine and Science in Sports and Exercise·Tuomo RankinenClaude Bouchard
May 1, 2007·Sports Medicine·Scott Trappe
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y A SaitoN J Talley
Sep 29, 2007·The Journal of Physiology·Alun G Williams, Jonathan P Folland
Dec 1, 2007·British Journal of Sports Medicine·B KnechtleG Kohler

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Citations

Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·C Holt, R Jenness
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·G L FletcherR F Addison
Sep 1, 1994·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S SuzukiR Tamatani
Sep 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S SuzukiR Tamatani
Jun 1, 1996·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S SuzukiT Takahashi
Oct 9, 2014·Sports Medicine·Veronica VleckFrancisco Bessone Alves
Mar 7, 2019·Journal of Sports Sciences·Beata PeplonskaCezary Zekanowski

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