The intermediate filament GFAP is important for the control of experimental murine Staphylococcus aureus-induced brain abscess and Toxoplasma encephalitis

Journal of Neuropathology and Experimental Neurology
Werner StenzelMartina Deckert

Abstract

The functional role of astrocytes exerted via their intermediate protein glial fibrillary acidic protein (GFAP) in CNS infections was studied in Staphylococcus aureus-induced brain abscess. Compared to wild type (WT) mice, GFAP(0/0) mice developed larger and more poorly demarcated inflammatory lesions paralleled by a significantly increased intracerebral bacterial load, a diffuse leukocytic infiltration of the contralateral hemisphere, purulent ventriculitis, vasculitis, and severe brain edema. These observations were correlated with the lack of a bordering function of activated astrocytes that strongly upregulated their GFAP expression in the abscess surrounding of WT mice. Clinically important, this lack of restriction of inflammation markedly aggravated the course of disease with manifestation of seizures and a severe weight loss in GFAP(0/0) mice. These data were paralleled by observations in the model of Toxoplasma encephalitis (TE) during which the intracerebral parasitic load was significantly increased. Moreover, tachyzoite-induced tissue necrosis was exclusively found in the brains of GFAP(0/0) mice in chronic TE. Collectively, these findings delineate a host defense function of astrocytes via restricting pathogenic sp...Continue Reading

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Citations

Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nirmal K PhulwaniTammy Kielian
Apr 16, 2008·Journal of Neurochemistry·Nirmal K Phulwani, Tammy Kielian
Dec 12, 2017·Annals of Neurology·Tracy L HagemannAlbee Messing
Apr 19, 2019·Journal of Leukocyte Biology·Aline L PachecoKarina R Bortoluci
Mar 16, 2019·Frontiers in Immunology·Dirk Schlüter, Antonio Barragan
Feb 18, 2005·Journal of Neuropathology and Experimental Neurology·Werner StenzelMartina Deckert
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Werner StenzelMartina Deckert
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katrin DrögemüllerDirk Schlüter
May 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Egle CekanaviciuteMarion S Buckwalter
Feb 20, 2019·Neurochemical Research·Tatyana Shulyatnikova, Alexei Verkhratsky
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Jul 8, 2020·Cells·Maja PotokarJernej Jorgačevski
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Jun 28, 2015·Experimental Parasitology·Gungor Cagdas Dincel, Hasan Tarik Atmaca

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