The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test

Toxicology in Vitro : an International Journal Published in Association with BIBRA
H SpielmannP G Brantom

Abstract

To date, no standardized international guideline for the testing of chemicals for phototoxic potential has been accepted for regulatory purposes. In 1991, the European Commission (EC), represented initially by the Directorate General XI and later by ECVAM (the European Centre for the Validation of Alternative Methods) and COLIPA (the European Cosmetic, Toiletry and Perfumery Association), agreed to establish a joint EU/COLIPA programme on the development and validation of in vitro phototoxicity tests. The first phase (phase I, 1992-93) was designed as a prevalidation study, to identify in vitro test procedures and test protocols for a formal validation trial under blind conditions. In the second phase (phase II, 1994-95), the formal validation study, the most promising in vitro phototoxicity tests were validated with 30 carefully selected test chemicals in 11 laboratories in a blind trial. The 3T3 mouse fibroblast neutral red uptake phototoxicity test (3T3 NRU PT) was performed as a core test in nine laboratories, since it provided the best results in phase I of the study. The purpose of phase II was to confirm the reliability and relevance of the in vitro tests for predicting phototoxic effects and for identifying phototoxic c...Continue Reading

References

May 1, 1992·Human & Experimental Toxicology·K Ungar
Jul 1, 1991·Journal of the American Academy of Dermatology·E HölzleG Plewig
Aug 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M LiebschH Spielmann
Aug 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H SpielmannA Willshaw

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Citations

Jun 29, 2013·International Journal of Pharmaceutics·César Burgos-DíazAna M Marqués
May 3, 2003·Regulatory Toxicology and Pharmacology : RTP·David R BickersHachiro Tagami
Jun 8, 2002·Toxicology Letters·Manfred Liebsch, Horst Spielmann
Feb 18, 1999·Toxicology Letters·J LeClaire, O de Silva
May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N J TraynorN K Gibbs
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L ReidN Khammo
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H Spielmann, M Liebsch
Jul 10, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P A JonesR S Lawrence
Nov 6, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P A Jones, A V King
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Balls, J H Fentem
Jan 28, 2003·Mutation Research·E GockeU Widmer
Jan 7, 2004·Mutation Research·Susanne Brendler-SchwaabDietmar Utesch
Oct 6, 2000·Journal of Biomolecular Structure & Dynamics·L B JørgensenJ P Jacobsen
Jul 8, 2009·Critical Reviews in Food Science and Nutrition·Ulf HammerlingNils-Gunnar Ilbäck
Feb 16, 2002·In Vitro & Molecular Toxicology·J F Sina
Feb 16, 2002·In Vitro & Molecular Toxicology·J MedinaA de Brugerolle de Fraissinette
Jul 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Giampietro ViolaFrancesco Dall'Acqua
Jan 4, 2012·Photochemistry and Photobiology·Ashish DwivediRatan S Ray
Nov 20, 2014·BMC Complementary and Alternative Medicine·Lilian F B AmaralPriscila G Mazzola
Aug 19, 2007·Journal of Pharmaceutical Sciences·M P Vinardell, M Mitjans
Jul 22, 2015·International Journal of Cosmetic Science·J E P S SilveiraS Eberlin
Jul 6, 2010·Regulatory Toxicology and Pharmacology : RTP·Mark H KleinmanChris D Geddes
Feb 2, 2010·Journal of Pharmacological and Toxicological Methods·Shahnaz Bakand, Amanda Hayes
Jan 12, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anthony M Lynch, Phillip Wilcox
Sep 22, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C F ZanattaM P Vinardell
Mar 4, 2011·The Journal of Investigative Dermatology·Tatsushi ToyookaYuko Ibuki
Nov 4, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·María Pilar VinardellRichard Clothier
Apr 29, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Horst SpielmannRichard Vogel
Mar 1, 2005·Basic & Clinical Pharmacology & Toxicology·Ulrike BernauerUrsula Gundert-Remy
May 26, 2007·Photodermatology, Photoimmunology & Photomedicine·Jong Hee LeeKwang Hyun Cho
Apr 6, 2006·Lasers in Surgery and Medicine·Eric F BernsteinSergey M Ksenzenko
Apr 12, 2016·European Journal of Medicinal Chemistry·Cyrille LescopMartin H Bolli
Mar 31, 2016·European Journal of Medicinal Chemistry·Martin H BolliBeat Steiner
Oct 13, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Nathalie DijouxPierre-Jacques Ferret

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