The international postpartum depression: action towards causes and treatment (PACT) consortium

International Review of Psychiatry
Jerry GuintivanoSamantha Meltzer-Brody

Abstract

The International Postpartum depression: Action towards Causes and Treatment (PACT) Consortium was founded with the overarching goal of creating an international perinatal psychiatry consortium to conduct novel investigations with large sample sizes to understand the genetic signature of perinatal mood disorders. PACT uses a collaborative and team science approach that includes investigators across 19 institutions and seven continents. The large sample sizes allow for statistically rigorous analyses to investigate perinatal psychiatric disorders, with an initial focus on postpartum depression (PPD). Our current aims are to identify clinical sub-types of PPD that contribute diagnostic heterogeneity, and to elucidate the genetic basis of PPD by conducting the first large genome-wide association study of PPD. To accomplish the latter aim, we are partnering with the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. To date, our consortium members have recruited 17,912 participants and 11,344 participants have been identified using the PPD ACT mobile app, of which 8,432 are PPD cases. Ultimately, we hope this approach will improve detection, diagnosis, and treatment of women who suffer from perinatal ps...Continue Reading

References

Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·J L CoxR Sagovsky
Jul 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·J L CoxG Chapman
Jul 19, 2002·The New England Journal of Medicine·Katherine L WisnerCatherine M Piontek
Jul 28, 2004·International Review of Psychiatry·L Burke
Sep 1, 2005·Archives of Women's Mental Health·R C BoydR Somberg
Dec 13, 2005·Journal of Affective Disorders·Kathleen Murphy-EberenzDouglas F Levinson
Sep 2, 2006·The American Journal of Psychiatry·Liz FortyIan Jones
May 15, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·C E Hewitt, S M Gilbody
Sep 17, 2009·The American Journal of Psychiatry·Pamela Belmonte MahonJames B Potash
Nov 10, 2009·Psychological Medicine·A CorvinP F Sullivan
Jan 23, 2010·Journal of Psychiatric Research·Javier CostasJulio Sanjuán
Feb 4, 2010·Archives of Women's Mental Health·Katherine L WisnerDorothy K Y Sit
Jul 3, 2010·The American Journal of Psychiatry·Thomas InselPhilip Wang
Jun 13, 2013·Methods in Molecular Biology·Ben Hayes
Jun 4, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Edward ChesneySeena Fazel
Jul 20, 2014·Archives of Women's Mental Health·Enda M ByrneNaomi R Wray
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Sep 30, 2014·CNS Spectrums·Crystal Edler SchillerDavid R Rubinow
Apr 18, 2015·PLoS Computational Biology·Christiaan A de LeeuwDanielle Posthuma
Sep 1, 2015·Hormones and Behavior·Susanne Brummelte, Liisa A M Galea
Sep 5, 2015·The American Journal of Psychiatry·Alexander ViktorinPatrik K E Magnusson
Sep 12, 2015·The Lancet. Psychiatry·UNKNOWN Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium
Sep 29, 2015·The New England Journal of Medicine·Joseph A SparanoGeorge W Sledge
Mar 5, 2016·The American Journal of Psychiatry·Benedicte Marie Winther JohannsenTrine Munk-Olsen
Aug 25, 2016·The New England Journal of Medicine·Fatima CardosoUNKNOWN MINDACT Investigators
Oct 19, 2016·Translational Psychiatry·T Munk-OlsenS Meltzer-Brody
Oct 26, 2016·The Journal of Clinical Psychiatry·Elizabeth Q CoxBradley N Gaynes
Oct 28, 2016·Nature Neuroscience·Gerome BreenHoward J Edenberg
Feb 17, 2017·MMWR. Morbidity and Mortality Weekly Report·Jean Y KoSherry L Farr
May 10, 2017·The Lancet. Psychiatry·Karen T PutnamUNKNOWN Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium
Apr 27, 2018·Nature Reviews. Disease Primers·Samantha Meltzer-BrodyJeannette Milgrom
Apr 28, 2018·Nature Genetics·Naomi R WrayUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Dec 1, 2018·Translational Psychiatry·Jerry GuintivanoSamantha Meltzer-Brody

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Citations

Sep 19, 2021·BMC Pregnancy and Childbirth·Guy AmitPinchas Akiva

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