The interobserver variability of digital rectal examination in a large randomized trial for the screening of prostate cancer

The Prostate
Claartje GosselaarFritz H Schröder

Abstract

To analyze to what extent the percentage of suspicious digital rectal examination (DRE) findings vary between examiners and to what extent the percentage of prostate cancers (PCs) detected in men with these suspicious findings varies between examiners. In the first screening round of the European Randomized study of Screening for PC (ERSPC) Rotterdam, 7,280 men underwent a PSA-determination and DRE of whom 2,102 underwent prostate biopsy (biopsy indication PSA > or = 4.0 ng/ml and/or suspicious DRE and/or TRUS). Descriptive statistics of DRE-outcome per PSA-range were used to determine the observer variability of six examiners. Because this analysis did not correct properly for other predictors of a suspicious DRE (PSA-level, biopsy indication, TRUS-outcome, prostate volume and age), a logistic regression analysis controlling for these explanatory variables was performed as well. In 2,102 men biopsied, 443 PCs were detected (PPV = 21%). For all PSA levels the percentage suspicious DRE varied between examiners from 4% to 28% and percentage PC detected in men with a suspicious DRE varied from 18% to 36%. Logistic regression analysis showed that three of six examiners considered DRE significantly more often abnormal than others (O...Continue Reading

References

Aug 1, 1993·British Journal of Urology·E VarenhorstK Pedersen
Sep 13, 2005·BJU International·Sandra A ArmatysLiang Cheng
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Dec 13, 2006·The Journal of Urology·E W SteyerbergF H Schröder
Sep 27, 2007·Journal of the National Cancer Institute·Gabriel P HaasGustavo de la Roza

❮ Previous
Next ❯

Citations

Aug 31, 2011·World Journal of Urology·Tobias KlatteMesut Remzi
Jul 15, 2009·Irish Journal of Medical Science·D M FanningR W G Watson
Jul 4, 2012·Nature Reviews. Urology·Lisa Murphy, R William Watson
May 21, 2014·Nature Reviews. Clinical Oncology·Albert J ChangHoward I Scher
Mar 12, 2011·Nature Reviews. Urology·Sheng Fei OonR William G Watson
Feb 13, 2013·Nature Reviews. Urology·Xinhai HuCarsten Stephan
Nov 20, 2012·The Journal of Urology·Matthew K TollefsonStephen A Boorjian
May 2, 2009·Magnetic Resonance Imaging Clinics of North America·Colm J McMahonNeil M Rofsky
Mar 17, 2009·The Journal of Urology·Donna Pauler AnkerstDipen J Parekh
Jan 7, 2011·Cancer·Adam C ReeseMatthew R Cooperberg
Oct 30, 2013·BJU International·James ThompsonUNKNOWN USANZ
Apr 8, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Arnout R AlbertsMonique J Roobol
Dec 11, 2014·Cancer·Zachary KlaassenStephen J Freedland
Nov 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Jiayi HuangLarry L Kestin
Mar 13, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heidi A van VugtMonique J Roobol
May 1, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Matteo FerroDaniela Terracciano
Aug 27, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ömer YilmazZeki Aktas
Sep 14, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Nuno Pereira-AzevedoMonique J Roobol
Feb 14, 2018·Journal of Magnetic Resonance Imaging : JMRI·Jing WangYu-Dong Zhang
Nov 27, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·John Victor PeterJohn L Moran
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Dragan IlicPhilipp Dahm
Jul 17, 2020·Cancer Management and Research·Christopher J McNallyDeclan J McKenna
Dec 31, 2020·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Akbar N AshrafiMonish Aron
Aug 5, 2021·Lab on a Chip·Chi-Ju KimKenneth J Pienta
Jul 7, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Shunsuke MiyamotoAkio Matsubara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.