The interphase mammalian chromosome as a structural system based on tensegrity

Journal of Theoretical Biology
Armando Aranda-Anzaldo

Abstract

Each mammalian chromosome is constituted by a DNA fiber of macroscopic length that needs to be fitted in a microscopic nucleus. The DNA fiber is subjected at physiological temperature to random thermal bending and looping that must be constrained so as achieve structural stability thus avoiding spontaneous rupturing of the fiber. Standard textbooks assume that chromatin proteins are primarily responsible for the packaging of DNA and so of its protection against spontaneous breakage. Yet the dynamic nature of the interactions between chromatin proteins and DNA is unlikely to provide the necessary long-term structural stability for the chromosomal DNA. On the other hand, longstanding evidence indicates that stable interactions between DNA and constituents of a nuclear compartment commonly known as the nuclear matrix organize the chromosomal DNA as a series of topologically constrained, supercoiled loops during interphase. This results in a primary level of DNA condensation and packaging within the nucleus, as well as in protection against spontaneous DNA breakage, independently of chromatin proteins which nevertheless increase and dynamically modulate the degree of DNA packaging and its role in the regulation of DNA function. Thu...Continue Reading

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Citations

Apr 9, 2013·Biophysical Journal·Jared R TangneyJeffrey H Omens
May 4, 2017·Journal of Cellular Biochemistry·David García-Vilchis, Armando Aranda-Anzaldo
Dec 21, 2016·Journal of Cellular Biochemistry·Evangelina Silva-SantiagoArmando Aranda-Anzaldo
Apr 16, 2019·Journal of Neuroscience Research·Myrna A R Dent, Armando Aranda-Anzaldo
Oct 23, 2019·The Journal of Cell Biology·Pan ChenDaniel L Levy
Jul 13, 2016·Journal of Neuroscience Research·Armando Aranda-Anzaldo, Myrna A R Dent

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