The interplay among dietary fat, sugar, protein and açai (Euterpe oleracea Mart.) pulp in modulating lifespan and reproduction in a Tephritid fruit fly.

Experimental Gerontology
Pablo LiedoSige Zou

Abstract

Macronutrient balance is a critical contributor in modulating lifespan and health. Consumption of diets rich in fruits and vegetables provides numerous health benefits. The interactions among macronutrients and botanicals and how they influence aging and health remain elusive. Here we employed a nutritional geometry approach to investigate the interplay among dietary fat, sugar, protein and antioxidant- and polyphenolic-rich freeze-dried açai pulp in modulating lifespan and reproductive output in the Mexican fruit fly, Anastrepha ludens (Loew). Individual flies were cultured on one of the 24 diets made from a combination of 1) sugar and yeast extract (SY) at four ratios, 2) palmitic acid, a saturated fat, at two concentrations and 3) freeze-dried açai pulp at three concentrations. Fat addition decreased lifespan in females on the sugar only diet and the diet with a low SY ratio, while decreasing lifetime reproductive output in flies on the diet with the low SY ratio when compared to SY ratio-matched low fat controls. Açai supplementation promoted survival, while decreasing lifetime reproductive output, in flies on diets with high fat and high sugar but not other diets when compared to diet-matched non-supplemented controls. The...Continue Reading

References

Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kwang Pum LeeDavid Raubenheimer
Mar 27, 2009·The American Journal of Clinical Nutrition·Joan Sabaté, Yen Ang
Dec 22, 2009·Nutrition·Undurti N Das
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Mar 17, 2011·Free Radical Biology & Medicine·Olga BoydSige Zou
Aug 2, 2011·Cell Metabolism·Matthew D W PiperStephen J Simpson

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