The interplay between bone healing and remodeling around dental implants.

Scientific Reports
Soroush Irandoust, Sinan Müftü

Abstract

Long-term bone healing/adaptation after a dental implant treatment starts with diffusion of mesenchymal stem cells to the wounded region and their subsequent differentiation. The healing phase is followed by the bone-remodeling phase. In this work, a mechano-regulatory cellular differentiation model was used to simulate tissue healing around an immediately loaded dental implant. All tissue types were modeled as poroelastic in the healing phase. Material properties of the healing region were updated after each loading cycle for 30 cycles (days). The tissue distribution in the healed state was then used as the initial condition for the remodeling phase during which regions healed into bone adapt their apparent density with respect to a homeostatic remodeling stimulus. The short- (bone healing) and long-term (bone remodeling) effects of initial implant micromotion during the healing phase were studied. Development of soft tissue was observed both in the coronal region due to high fluid velocity, and on the vertical sides of the healing-gap due to high shear stress. In cases with small implant micromotion, tissue between the implant threads differentiated into bone during the healing phase but resorbed during remodeling. In cases w...Continue Reading

References

Jan 1, 1979·Journal of Biomechanics·S C Cowin, W C Van Buskirk
Jan 1, 1978·Journal of Biomechanics·S C Cowin, W C Van Buskirk
Mar 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K SøballeC Bünger
Sep 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G S BeaupréD R Carter
Jan 1, 1988·Journal of Biomechanics·R T WhalenC R Steele
Sep 1, 1987·The Anatomical Record·H M Frost
Sep 1, 1983·The Journal of Prosthetic Dentistry·P I Brånemark
May 14, 1998·Journal of Periodontology·A PiattelliM Paolantonio
Jun 10, 1998·Journal of Biomedical Materials Research·S Szmukler-MonclerJ H Dubruille
Jan 26, 1999·Clinical Orthopaedics and Related Research·T A Einhorn
Jul 24, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·U MeyerU Joos
Mar 13, 2002·Clinical Implant Dentistry and Related Research·R GlauserP Schärer
May 21, 2003·Clinical Oral Implants Research·Tord BerglundhJan Lindhe
May 21, 2003·Clinical Oral Implants Research·Emeka NkenkeFriedrich Wilhelm Neukam
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·R HuiskesK Søballe
Jan 15, 2005·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·V CrupiH Van Oosterwyck
Apr 19, 2005·Cancer Research·Akira NakamizoFrederick F Lang
Aug 17, 2005·Injury·Rozalia DimitriouPeter V Giannoudis
Oct 11, 2005·Journal of Biomechanics·Sandra J ShefelbineUlrich Simon
May 5, 2006·Clinical Oral Implants Research·Natalia Lioubavina-HackThorkild Karring
Dec 2, 2006·Dental Materials : Official Publication of the Academy of Dental Materials·Jianying LiNick Silikas
Dec 19, 2006·Bone·Philipp LeuchtJill A Helms
Apr 9, 2008·Journal of Biomechanics·Hsuan-Yu ChouS Müftü
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Daniel LinMichael Swain
Dec 25, 2010·Computer Methods and Programs in Biomedicine·J C Vanegas-AcostaM C Casale R
Apr 15, 2011·Injury·Richard Marsell, Thomas A Einhorn
Jan 29, 2013·Journal of Biomechanics·Hsuan-Yu Chou, Sinan Müftü
Jan 30, 2015·Journal of Dental Research·J Y ChaJ A Helms
Aug 28, 2015·Journal of the Royal Society, Interface·A F PereiraS J Shefelbine

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Citations

May 26, 2021·Scientific Reports·Nupur KohliRichard J van Arkel
Aug 13, 2021·European Journal of Dentistry·Karina Tiemi Sanomya TsumanumaRafael Pino Vitti

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