The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.

Cell Reports
Ola GrimsholmRita Carsetti

Abstract

Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age. Heavy chain variable region (VH) usage, somatic mutation frequency replacement-to-silent ratio, and CDR3 property changes, reflecting consecutive selection of highly antigen-specific, low cross-reactive antibody variants, all demonstrate that CD27dull and CD27bright MBCs represent sequential MBC developmental stages, and stringent antigen-driven pressure selects CD27dull into the CD27bright MBC pool. Dynamics of human MBCs are exploited in pregnancy, when 50% of maternal MBCs are lost and CD27dull MBCs transit to the more differentiated CD27bright stage. In the postpartum period, the maternal MBC pool is replenished by the expansion of persistent CD27dull clones. Thus, the stability and flexibility of human B cell memory is ensured by CD27dull MBCs that expand and differentiate in response to change.

Citations

Sep 17, 2020·Journal of Clinical Medicine·Nadia NathanHarriet Corvol
Jun 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Nadezhda N LogunovaOlga V Britanova
Feb 9, 2021·Frontiers in Immunology·Eleanor C SemmesGenevieve G Fouda
Apr 26, 2020·The Journal of Allergy and Clinical Immunology·Isabella QuintiAlessandro Plebani
May 12, 2020·The Journal of Allergy and Clinical Immunology·Enrico MaggiLorenzo Moretta
Feb 26, 2021·Current Opinion in Pulmonary Medicine·Rita CarsettiFranco Locatelli
Sep 18, 2020·Cell Host & Microbe·Sandra C A NielsenScott D Boyd
Apr 24, 2021·Frontiers in Cellular and Infection Microbiology·Isabella QuintiRita Carsetti
May 15, 2020·Stem Cell Reviews and Reports·Benjamin Debuc, David M Smadja
May 25, 2021·Journal of Virus Eradication·Salvatore ZaffinaCarlo Federico Perno
Jul 30, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M HelmR Freitag
Aug 10, 2021·Frontiers in Immunology·Michela CioccaEva Piano Mortari

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