The interplay between immunity and aging in Drosophila

F1000Research
Kathrin Garschall, Thomas Flatt

Abstract

Here, we provide a brief review of the mechanistic connections between immunity and aging-a fundamental biological relationship that remains poorly understood-by considering two intertwined questions: how does aging affect immunity, and how does immunity affect aging? On the one hand, aging contributes to the deterioration of immune function and predisposes the organism to infections ("immuno-senescence"). On the other hand, excessive activation of the immune system can accelerate degenerative processes, cause inflammation and immunopathology, and thus promote aging ("inflammaging"). Interestingly, several recent lines of evidence support the hypothesis that restrained or curbed immune activity at old age (that is, optimized age-dependent immune homeostasis) might actually improve realized immune function and thereby promote longevity. We focus mainly on insights from Drosophila, a powerful genetic model system in which both immunity and aging have been extensively studied, and conclude by outlining several unresolved questions in the field.

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Citations

Aug 21, 2018·BMC Biology·Thomas Flatt, Linda Partridge
Dec 20, 2018·Evolution Letters·Daniel K FabianThomas Flatt
Apr 22, 2020·Nature Ecology & Evolution·Emily J BrownDoris Bachtrog
Aug 24, 2018·International Journal of Molecular Sciences·Kyung-Jin Min, Marc Tatar
Dec 14, 2019·Current Opinion in Immunology·Mark Austin Hanson, Bruno Lemaitre
Dec 16, 2019·Ageing Research Reviews·Antero Salminen
Apr 6, 2018·Journal of Agricultural and Food Chemistry·Stefanie StaatsGerald Rimbach

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Methods Mentioned

BETA
transgenic

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