The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis

Cell Regeneration
S T Ngo, F J Steyn

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is characterized by the selective degeneration of upper motor neurons and lower spinal motor neurons, resulting in the progressive paralysis of all voluntary muscles. Approximately 10 % of ALS cases are linked to known genetic mutations, with the remaining 90 % of cases being sporadic. While the primary pathology in ALS is the selective death of upper and lower motor neurons, numerous studies indicate that an imbalance in whole body and/or cellular metabolism influences the rate of progression of disease. This review summarizes current research surrounding the impact of impaired metabolic physiology in ALS. We extend ideas to consider prospects that lie ahead in terms of how metabolic alterations may impact the selective degeneration of neurons in ALS and how targeting of adenosine triphosphate-sensitive potassium (KATP) channels may represent a promising approach for obtaining neuroprotection in ALS.

References

Jan 1, 1977·Clinical Neurology and Neurosurgery·R Van den BerghE Meulepas
Jan 1, 1990·Pflügers Archiv : European journal of physiology·M L AshfordJ M Treherne
Jul 1, 1988·Journal of Computer Assisted Tomography·J HatazawaG Di Chiro
Nov 1, 1987·Annals of Neurology·M C DalakasG Di Chiro
Jan 1, 1985·Journal of Neurology·Y MasuiK Kakehi
Mar 1, 1984·Journal of the Neurological Sciences·E T ReyesW V Moore
Feb 1, 1995·Brain : a Journal of Neurology·H BostockN M Murray
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Sep 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R G GiffardD W Choi
Jan 1, 1996·The American Journal of Clinical Nutrition·E J KasarskisC J McClain
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P G BittarP J Magistretti
May 1, 1997·Journal of Neurology·P J Shaw, P G Ince
May 1, 1997·Neuron·J P ClementJ Bryan
Jan 10, 1998·The Journal of General Physiology·S Shyng, C G Nichols
Jan 22, 1998·Biochemical and Biophysical Research Communications·M SuzukiK Takata
Feb 12, 1998·The American Journal of Physiology·H YokoshikiN Sperelakis
Apr 29, 1998·Journal of the Neurological Sciences·F R WiedemannW S Kunz
Sep 3, 1998·Diabetologia·D PorteM W Schwartz
Oct 21, 1998·Developmental Neuroscience·L PellerinP J Magistretti
Feb 11, 1999·Neurochemical Research·L Sokoloff
Sep 25, 1999·Neurology·J C DesportP Couratier
Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·M Guzmán, C Blázquez
Apr 25, 2001·Nature Neuroscience·B E LevinV H Routh
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Aug 28, 2001·The American Journal of Clinical Nutrition·J C DesportP Couratier
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Oct 26, 2001·Journal of the Neurological Sciences·G SicilianoL Murri
Dec 18, 2001·Journal of Neuroscience Research·G A Dienel, L Hertz
Feb 13, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B E Levin
Feb 14, 2002·Journal of Neurochemistry·Falk R WiedemannEric A Schon
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dong LiuMark P Mattson

❮ Previous
Next ❯

Citations

Feb 26, 2016·Frontiers in Physiology·Chimeglkham BanzraiRyuji Kaji
Oct 30, 2016·Frontiers in Molecular Neuroscience·Stefanie KrügerSaskia Biskup
Aug 31, 2017·Neurotoxicity Research·Vanessa X TanGilles J Guillemin
Jan 9, 2019·Frontiers in Cellular Neuroscience·Kathleen JordanCassie S Mitchell
Aug 24, 2018·Brain : a Journal of Neurology·Vladislav A PetyukAmanda J Myers
Oct 17, 2019·Frontiers in Neuroscience·Vanessa X Tan, Gilles J Guillemin
Apr 4, 2021·Cells·Silvia ScaricamazzaCristiana Valle
May 28, 2021·Neurobiology of Aging·Margarita GerouScott P Allen
Jan 30, 2021·Journal of Neuroendocrinology·Shyuan T NgoFrederik J Steyn

❮ Previous
Next ❯

Methods Mentioned

BETA
Profiler
PCR

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

ALS & FTD: TDP-43

TAR DNA-binding protein 43 (TDP-43) is a pathological protein identified in sporadic Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Here are the latest discoveries pertaining to TDP-43 and these diseases.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.