The interplay between microRNAs and Twist1 transcription factor: a systematic review

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hashem KhanbabaeiMilad Mohammadi

Abstract

Twist1 (also known as Twist) is a transcription factor that belongs to the family of basic helix-loop-helix (bHLH) proteins. It functions as a negative regulator of epithelial gene expression and a positive regulator of mesenchymal gene expression, thereby leading to induction of the epithelial mesenchymal transition (EMT), a process in which epithelial cells acquire the motile and migratory characteristics of mesenchymal cells. In addition to regulating the expression of protein-coding genes, Twist1 regulates the expression of microRNAs (miRNAs), adding a regulatory layer to EMT induction. Interestingly, the mRNA of Twist1 represents a downstream target of miRNAs, indicating an intricate network between miRNAs and Twist1. This network was shown to play multiple roles in cancer cell migration, invasion, and metastasis. The network can induce angiogenesis, protect cells from oncogene-induced apoptosis and senescence, enhance cancer cell resistance to conventional therapies, and increase cancer stem cell (CSC) populations. Recently, miRNAs have attracted considerable attention as potential promising tools in cancer therapies. Thus, this systematic review was conducted to clarify the reciprocal link between Twist1 and miRNAs in or...Continue Reading

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Citations

Jan 31, 2018·Scientific Reports·Patrice PenfornisRadhika R Pochampally
May 2, 2017·Acta Biochimica Et Biophysica Sinica·Feng LiuZhenyu Ma
Nov 30, 2018·Journal of Cellular Biochemistry·Mohammad-Javad Tahmasebi-BirganiHashem Khanbabaei
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Nov 13, 2019·Mutation Research·Mohammad-Taghi Bahreyni-ToossiHosein Azimian
Sep 10, 2020·Kidney Diseases·Jiafa Ren, Steven D Crowley

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