The Interplay Between Nanoparticles and Neutrophils

Journal of Biomedical Nanotechnology
Ming-Hsien LinJia-You Fang

Abstract

The employment of nanoparticles has markedly increased in recent years for different applications such as aerospace technology, electronics, biology, and medicine. The exposure of nanoparticles to humans is inevitable nowadays. Neutrophils act as the predominant phagocytic cells for first-line defense to be recruited to an inflammatory site against xenobiotics. It is important to explore how neutrophils interact with nanoparticles to elicit immune responses. Different types of nanoparticles have been studied to reveal a potential interaction to neutrophils in vitro and in vivo. These mainly include metallic nanoparticles, polymeric nanoparticles, silica nanoparticles, lipid nanoparticles, and fullerenes. A number of investigations have reported the toxicity of nanoparticles induced by neutrophil activation. In this review we discuss data demonstrating recently recognized aspects of inflammation induced by overwhelmed neutrophils after nanoparticle treatment. Besides the dark side of the nanoparticles, some therapeutic nanoparticles are developed and beneficial in treating neutrophil-related diseases such as acute lung injury, vascular inflammation, and bacterial infection. Some nanoparticles can recruit neutrophils around tumor...Continue Reading

Citations

Sep 4, 2019·Drug and Chemical Toxicology·Mariana Appel HortFlavio Manoel Rodrigues da Silva Júnior
Sep 27, 2019·Current Pharmaceutical Design·Romina MitarotondaMauricio C De Marzi
Jan 29, 2019·Frontiers in Immunology·Débora TorrealbaDaniel R Barreda
Sep 21, 2019·Future Medicinal Chemistry·Ming-Hsien LinJia-You Fang
Dec 22, 2020·Trends in Pharmacological Sciences·Lucas M BushTara L Deans
May 7, 2021·Journal of Immunotoxicology·Leonor de BragancaJeremy P Derrick
Sep 10, 2019·ACS Biomaterials Science & Engineering·Paul W BissoRobert Langer
Oct 30, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Wali MuhammadChangyou Gao

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