The interplay between neuropathology and activity based rehabilitation after traumatic brain injury

Brain Research
Lisa A Kreber, Grace S Griesbach

Abstract

Exercise has been shown to facilitate the release of molecules that support neuroplasticity and to offer protection from brain damage. This article addresses the mechanisms behind exercise׳s beneficial effects within the context of traumatic brain injury (TBI). First, we describe how ongoing metabolic, neuroendocrine and inflammatory alterations after TBI interact with exercise. Given the dynamic nature of TBI-initiated pathophysiological processes, the timing, intensity and type of exercise need to be considered when implementing exercise. These factors have been shown to be important in determining whether exercise enhances or impedes neuroplasticity after TBI. In point of fact, intense exercise during the acute post-injury period has been associated with worsened cognitive performance. Similarly, exercise that is associated with a pronounced increase of stress hormones can inhibit the expression of brain derived neurotrophic factor that is usually increased with exercise. Second, we describe the clinical implications of these findings in returning to play following TBI. Finally, we address therapeutic exercise interventions in the context of rehabilitation following TBI. Exercise is likely to play an important role in improv...Continue Reading

References

Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KawamataD P Becker
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K R IsaacsW T Greenough
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E BlackW T Greenough
Jul 1, 1983·Pflügers Archiv : European journal of physiology·W KuschinskyL Sokoloff
Jan 1, 1984·Neurobiology of Aging·R E DustmanD C Bradford
Apr 1, 1995·Current Opinion in Neurobiology·B S McEwen, R M Sapolsky
Apr 24, 1995·Archives of Internal Medicine·C GuilleminaultD Claman
Jan 12, 1995·Nature·S A NeeperC Cotman
Dec 29, 1995·Annals of the New York Academy of Sciences·M A SmithR M Post
Jun 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·I J BaguleyL D Wade
Jul 10, 1999·Neuroscience Letters·M NibuyaR S Duman
Aug 10, 1999·Nature·A F KramerA Colcombe
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Feb 5, 2000·Journal of Applied Physiology·F W BoothM T Hamilton
Aug 12, 2000·Stress : the International Journal on the Biology of Stress·M J SchaafE Vreugdenhil
Aug 18, 2000·Seminars in Neurology·B D Jordan
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A H MooreS R Cherry
Jun 26, 2001·American Journal of Physical Medicine & Rehabilitation·R M ShavelleY L Yu
Aug 16, 2001·The Journal of Nervous and Mental Disease·J F Friedland, D R Dawson
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Apr 17, 2002·The Journal of Physiology·Mads K DalsgaardNiels H Secher
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·J R de KruijkA Twijnstra
Mar 29, 2003·Psychological Science·Stanley Colcombe, Arthur F Kramer
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Kevin M GuskiewiczJames P Kelly
Dec 6, 2003·The European Journal of Neuroscience·Klaus FabelTheo D Palmer
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mads K DalsgaardNiels H Secher
Jun 15, 2004·Brain Pathology·Ramesh Raghupathi
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·C Lopez-LopezI Torres-Aleman
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla

❮ Previous
Next ❯

Citations

Nov 14, 2017·Neurorehabilitation and Neural Repair·Patricia B de la TremblayeAnthony E Kline
Apr 30, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Phyllis Berger
Oct 24, 2018·NeuroRehabilitation·Stefanie Howell, Grace S Griesbach
Dec 4, 2019·Frontiers in Neuroscience·Michel Modo
Dec 7, 2020·Behavioural Brain Research·Laura Martínez-DrudisMargalida Coll-Andreu
Aug 16, 2021·Journal of Bodywork and Movement Therapies·Susan Vaughan Kratz, Daniel J Kratz
Sep 23, 2021·Journal of the International Neuropsychological Society : JINS·Aliyah R SnyderRussell M Bauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.