The interplay between neutrophils, complement, and microthrombi in COVID-19.

Best Practice & Research. Clinical Rheumatology
Yu ZuoAlfred H J Kim

Abstract

As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system, and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here, we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology, and highlight potential therapeutic strategies to combat these pathways.

References

Aug 1, 1989·International Journal of Food Microbiology·H Korkeala, P Mäkelä
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Mar 6, 2004·Science·Volker BrinkmannArturo Zychlinsky
Aug 11, 2004·The Journal of Biological Chemistry·Sibylla MartinelliShida Yousefi
Aug 3, 2010·Nature Medicine·Steffen MassbergBernd Engelmann
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tobias A FuchsDenisa D Wagner
Feb 5, 2011·Virology·Kristina A Stoermer, Thomas E Morrison
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonatan LefflerAnna M Blom
Mar 28, 2012·The Journal of Experimental Medicine·Marie-Luise von BrühlSteffen Massberg
Jun 7, 2013·The New England Journal of Medicine·C M LegendreC Loirat
Jul 3, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Julian I BorissoffBas L J H Kietselaer
Sep 24, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yasuyuki AraiAkifumi Takaori-Kondo
Dec 21, 2013·Journal of Innate Immunity·Joseph O'FlynnCees van Kooten
Feb 7, 2014·Annual Review of Immunology·V Michael Holers
Jul 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martina BehnenTamás Laskay
Sep 28, 2014·Annals of the Rheumatic Diseases·Eirini ApostolidouKonstantinos Ritis
Nov 25, 2014·Journal of Thrombosis and Haemostasis : JTH·M Jiménez-AlcázarT A Fuchs
Feb 14, 2015·European Journal of Clinical Investigation·Dimitrios C MastellosJohn D Lambris
Apr 23, 2015·Journal of Periodontal Research·L J PalmerC H Nielsen
May 13, 2015·Clinical and Experimental Immunology·H WangM Chen
Oct 16, 2015·The Journal of Pathology·Bart CortjensReinout A Bem
May 28, 2016·Journal of Innate Immunity·Maria Victoria RamosMarina Sandra Palermo
Jul 19, 2016·Arthritis & Rheumatology·Yasuko FurumotoMassimo Gadina
Oct 5, 2016·Frontiers in Immunology·Günther Schönrich, Martin J Raftery
Dec 14, 2016·Annual Review of Pathology·M Kathryn LiszewskiJohn P Atkinson
Feb 16, 2017·Molecular Immunology·M Kathryn LiszewskiJohn P Atkinson
Jul 4, 2017·Frontiers in Microbiology·Palak AgrawalArvind Sahu
Sep 14, 2017·Autoimmunity Reviews·Keum Hwa LeeJae Il Shin
Jun 3, 2018·Journal of the American Society of Nephrology : JASN·Sjoerd A M E G TimmermansUNKNOWN Limburg Renal Registry
Apr 17, 2019·The Journal of Clinical Investigation·Vinita YadavYogendra Kanthi
Apr 25, 2019·Nature Communications·Ramadan A AliJason S Knight
Jul 3, 2019·Thrombosis and Haemostasis·Eleni GavriilakiAchilles Anagnostopoulos
Jul 19, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Charlotte ThålinHåkan Wallén
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Mar 3, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sufang TianShu-Yuan Xiao

❮ Previous
Next ❯

Citations

Feb 25, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Richard ConwayAlfred H J Kim
Mar 31, 2021·Scandinavian Journal of Immunology·Juan Bautista De SanctisMarián Hajduch
May 26, 2021·Cell Death and Differentiation·Maximilian AckermannMartin Herrmann
Jun 11, 2021·Circulation Research·Meaghan E CollingYogendra Kanthi
Sep 3, 2021·Immunity, Inflammation and Disease·Yuan MaLiuluan Zhu
Jun 16, 2021·Current Opinion in Pulmonary Medicine·Thomas M CascinoYogendra Kanthi

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
biopsy

Clinical Trials Mentioned

NCT04355364
NCT04359654
NCT04391179
NCT04424901
NCT04346797
NCT04355494
NCT04369469
NCT04390464
NCT04382755
NCT04333420

Software Mentioned

COVASE
COVIDornase

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.