The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics

Antioxidants
Sarbajeet Nagdas, David F Kashatus

Abstract

Mitochondria are dynamic organelles that alter their organization in response to a variety of cellular cues. Mitochondria are central in many biologic processes, such as cellular bioenergetics and apoptosis, and mitochondrial network morphology can contribute to those physiologic processes. Some of the biologic processes that are in part governed by mitochondria are also commonly deregulated in cancers. Furthermore, patient tumor samples from a variety of cancers have revealed that mitochondrial dynamics machinery may be deregulated in tumors. In this review, we will discuss how commonly mutated oncogenes and their downstream effector pathways regulate the mitochondrial dynamics machinery to promote changes in mitochondrial morphology as well as the physiologic consequences of altered mitochondrial morphology for tumorigenic growth.

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Citations

Mar 29, 2019·The Journal of Clinical Investigation·Patricia Santofimia-CastañoJuan Iovanna
May 8, 2020·In Vitro Cellular & Developmental Biology. Animal·Kun-Lin ChenGuang-Dong Xing
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Oct 17, 2020·Neural Regeneration Research·Katherine DaiDonna Leonardi
May 5, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnau Navinés-FerrerMargarita Martin

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Methods Mentioned

BETA
GTPases
GTPase
ubiquitination
sumoylation
xenografts
xenograft
nucleotide exchange

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