The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer's Disease.

Molecular Neurobiology
Tapan BehlSimona Bungau

Abstract

The occurrence of Alzheimer's disease (AD) worldwide has been progressively accelerating at an alarming rate, without any successful therapeutic strategy for the disease mitigation. The complexity of AD pathogenesis needs to be targeted with an alternative approach, as provided by the superfamily of ATP-binding cassette (ABC) transporters, which constitutes an extensive range of proteins, capable of transporting molecular entities across biological membranes. These protein moieties have been implicated in AD, based upon their potential in lipid transportation, resulting in maintenance of cholesterol homeostasis. These transporters have been reported to target the primary hallmark of AD pathogenesis, namely, beta-amyloid hypothesis, which is associated with accumulation of beta-amyloid (Aβ) plaques in AD patients. The ABC transporters have been observed to be localized to the capillary endothelial cells of the blood-brain barrier and neural parenchymal cells, where they exhibit different roles, consequently influencing the neuronal expression of Aβ peptides. The review highlights different families of ABC transporters, ABCB1 (P-glycoprotein), ABCA (ABCA1, ABCA2, and ABCA7), ABCG2 (BCRP; breast cancer resistance protein), ABCG1 a...Continue Reading

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Citations

May 1, 2021·International Journal of Molecular Sciences·Sweilem B Al RihaniVeronique Michaud
May 1, 2021·International Journal of Molecular Sciences·Tapan BehlCiprian Brisc
Jun 19, 2021·Computational and Structural Biotechnology Journal·Vigneshwaran NamasivayamSven Marcel Stefan
Aug 21, 2021·Essays in Biochemistry·Jared S Katzeff, Woojin Scott Kim

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Methods Mentioned

BETA
transgenic
lipidation
genotyping

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