The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin

Current Genetics
Alexis Zukowski, Aaron Johnson

Abstract

Mono-ubiquitinated histone H2B (H2B-Ub) is important for chromatin regulation of transcription, chromatin assembly, and also influences heterochromatin. In this review, we discuss the effects of H2B-Ub from nucleosome to higher-order chromatin structure. We then assess what is currently known of the role of H2B-Ub in heterochromatic silencing in budding and fission yeasts (S. cerevisiae and S. pombe), which have distinct silencing mechanisms. In budding yeast, the SIR complex initiates heterochromatin assembly with the aid of a H2B-Ub deubiquitinase, Ubp10. In fission yeast, the RNAi-dependent pathway initiates heterochromatin in the context of low H2B-Ub. We examine how the different silencing machineries overcome the challenge of H2B-Ub chromatin and highlight the importance of using these microorganisms to further our understanding of H2B-Ub in heterochromatic silencing pathways.

References

Sep 22, 1999·Molecular and Cellular Biology·A Kahana, D E Gottschling
Jan 19, 2000·Nature·B D Strahl, C D Allis
Jan 22, 2000·Science·K RobzykM A Osley
Mar 9, 2002·Molecular and Cellular Biology·Cherie L Mueller, Judith A Jaehning
Jun 28, 2002·Cell·Fred van LeeuwenDaniel E Gottschling
Aug 2, 2002·Nature·Scott D BriggsBrian D Strahl
Feb 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huck Hui NgKevin Struhl
Jul 29, 2004·The Journal of Biological Chemistry·Helena Santos-RosaTony Kouzarides
Jan 20, 2005·Molecular and Cellular Biology·Kenneth K LeeJerry L Workman
May 28, 2005·The EMBO Journal·Yael Katan-Khaykovich, Kevin Struhl
Mar 17, 2007·The Journal of Biological Chemistry·Martin Zofall, Shiv I S Grewal
Jul 11, 2008·Molecular Cell·Alastair B FlemingMary Ann Osley
Jun 23, 2009·Nature Genetics·Erin A OsborneJasper Rine
Jul 25, 2009·Nature Reviews. Molecular Cell Biology·David KomanderSylvie Urbé
Jul 25, 2009·The EMBO Journal·Brian Luke, Joachim Lingner
Sep 29, 2009·Molecular Cell·Aaron JohnsonDanesh Moazed
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mahesh B ChandrasekharanZu-Wen Sun
Dec 17, 2009·Nucleic Acids Research·Yakun WanJohn D Aitchison
Jan 5, 2011·Nature Chemical Biology·Beat FierzTom W Muir
May 3, 2011·Annual Review of Biochemistry·Tamaki Suganuma, Jerry L Workman
Jun 15, 2011·The EMBO Journal·Mariano OppikoferSusan M Gasser
Nov 8, 2011·Genes & Development·Julia M SchulzeMichael S Kobor
Nov 8, 2011·Genes & Development·Kiran BattaB Franklin Pugh
Apr 17, 2012·The Journal of Biological Chemistry·Ariane RacineJason C Tanny
Jul 26, 2012·PLoS Genetics·Alfonso Gallego-SánchezAvelino Bueno
Oct 30, 2012·Molecular Cell·Kelly M Trujillo, Mary Ann Osley
Nov 6, 2012·Genes & Development·Tasuku KitadaMichael Grunstein
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Feng WangDanesh Moazed
Sep 11, 2013·Annual Review of Genetics·Stephanie KuengSusan M Gasser
Sep 13, 2013·Biochemical and Biophysical Research Communications·Byung-Ho RhieSeong Hoon Ahn
Aug 22, 2014·EMBO Reports·Hanneke VlamingFred van Leeuwen
Mar 26, 2015·Nature·Katarzyna Maria KowalikMarc Bühler

❮ Previous
Next ❯

Citations

Jul 6, 2018·Current Genetics·Hiroaki KatoTakeshi Urano
Sep 12, 2018·Nucleic Acids Research·Tibor van WelsemFred van Leeuwen
Mar 3, 2019·Cells·Meagan Jezek, Erin M Green

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination
deubiquitination
histone acetylation
two-hybrid
RITS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.