The Interplay of Viral and Host Factors in Chikungunya Virus Infection: Targets for Antiviral Strategies

Viruses
Kai Zhi Wong, Justin Jang Hann Chu

Abstract

Chikungunya virus (CHIKV) has re-emerged as one of the many medically important arboviruses that have spread rampantly across the world in the past decade. Infected patients come down with acute fever and rashes, and a portion of them suffer from both acute and chronic arthralgia. Currently, there are no targeted therapeutics against this debilitating virus. One approach to develop potential therapeutics is by understanding the viral-host interactions. However, to date, there has been limited research undertaken in this area. In this review, we attempt to briefly describe and update the functions of the different CHIKV proteins and their respective interacting host partners. In addition, we also survey the literature for other reported host factors and pathways involved during CHIKV infection. There is a pressing need for an in-depth understanding of the interaction between the host environment and CHIKV in order to generate potential therapeutics.

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Citations

Mar 14, 2019·Open Biology·Liliana Echavarria-ConsuegraFulvio Reggiori
Mar 20, 2020·Pathogens and Global Health·Idris Nasir AbdullahiBamidele Soji Oderinde
Apr 7, 2020·Expert Opinion on Therapeutic Patents·Ritu Ghildiyal, Reema Gabrani
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vanessa Shi Li GohJustin Jang Hann Chu
Jun 11, 2019·Expert Opinion on Drug Discovery·María-Jesús Pérez-PérezEva-María Priego
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kowit HengphasatpornThanyada Rungrotmongkol
Jan 2, 2021·Frontiers in Public Health·Friederike I L Hucke, Joachim J Bugert
Dec 8, 2020·Frontiers in Molecular Biosciences·Sabna KottaPran Kishore Deb
Mar 11, 2021·PloS One·Sarawut KhongwichitYong Poovorawan
Mar 17, 2021·Archives of Biochemistry and Biophysics·Nitika GauravAshok Kumar Patel
Aug 27, 2021·The Journal of General Virology·Israel Guerrero-ArgueroBrett E Pickett

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Methods Mentioned

BETA
immunoprecipitation
two-hybrid
transfection
GTPase

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