PMID: 7992326Sep 1, 1994Paper

The interpretation of intensity and aggregation data for infections of Schistosoma haematobium

Transactions of the Royal Society of Tropical Medicine and Hygiene
M E WoolhouseD J Bradley

Abstract

The relationships between mean intensities of infection, the aggregation of infection among hosts, and host age are analysed using data from 2 large (> 3000 individuals) field studies of Schistosoma haematobium infection. The data show a convex relationship between mean intensity and age, a convex relationship between an inverse index of aggregation and age, and an age-dependent relationship between the mean and aggregation of infection intensity when levels of infection are high. These patterns are qualitatively compared with the output of mathematical models based on an immigration-death process (model I), and incorporating age-dependent changes in the distribution of exposure to infection as suggested by field data (model II), or reductions in the rate of infection as a function of either current (model III) or cumulative (model IV) parasite burdens, that is, density-dependent processes without or with memory, respectively. Models II and III were able to reproduce observed patterns, but model IV, which is a possible representation of acquired immunity, was not. These results are consistent with the following assumptions: (i) age-related patterns of aggregation can be generated without recourse to density-dependent processes;...Continue Reading

References

Jun 27, 1991·Nature·M E WoolhouseS K Chandiwana
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A WilkinsS Tulloch
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·D J Bradley, F S McCullough
Feb 1, 1983·Experimental Parasitology·D A Dean
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A WilkinsP J Moore
Jan 1, 1984·Transactions of the Royal Society of Tropical Medicine and Hygiene·H A WilkinsP J Moore
Aug 1, 1993·Acta Tropica·R D Gregory, M E Woolhouse
Jan 1, 1990·Parasitology Today·R A Wilson

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Citations

Oct 1, 1995·Parasitology Today·M E Woolhouse
Aug 26, 1998·Mathematical Biosciences·M S Chan, V S Isham
Aug 1, 1996·Tropical Medicine & International Health : TM & IH·M E WoolhouseS K Chandiwana
Dec 17, 1998·Tropical Medicine & International Health : TM & IH·C NeedhamD A Bundy
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M G Basáñez, M Boussinesq
Jun 6, 2020·Tropical Medicine & International Health : TM & IH·Tariro L Mduluza-JokonyaTakafira Mduluza

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