The interrelation of birth weight and regional lipid deposition: a twins study

Metabolism: Clinical and Experimental
Tien-Ming HngCampbell H Thompson

Abstract

This study examined the hypothesis that low birth weight is associated with changes in regional lipid deposition as well as insulin sensitivity in adult twins. Eleven adult female twin pairs were studied by magnetic resonance to determine regional adiposity. Their insulin sensitivity was assessed by the homeostasis model assessment. There were significant associations between birth weight and current homeostasis model assessment value (r=-0.528, P=.012), abdominal visceral (r=-0.581, P=.005), and subcutaneous fat volumes (r=-0.638, P=.001) if the group of 22 subjects were analyzed as individuals. There were no significant associations of the intratwin pair difference in birth weight and differences between adult twins in these same variables possibly because of limited patient numbers. Reduced birth weight does confer an increased risk of abdominal adiposity as well as insulin resistance in twin populations as it does in the general population.

References

Jun 29, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·S BoG Pagano
Jun 25, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I Rogers, UNKNOWN EURO-BLCS Study Group
May 6, 2004·The Journal of Pediatrics·Craig A JefferiesWayne S Cutfield

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Citations

Dec 11, 2007·Anais Da Academia Brasileira De Ciências·Nicolas WiernspergerEliete Bouskela

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