PMID: 9630849Jun 19, 1998Paper

The intestinal absorption of cadmium increases during a common viral infection (coxsackie virus B3) in mice

Chemico-biological Interactions
A W GlynnNils-Gunnar Ilbäck

Abstract

Murine intestinal absorption, tissue accumulation and redistribution of 109Cd during infection were studied using the common human virus Coxsackie virus B3 (CB3) adapted to the mouse. Female Balb/c mice were infected with CB3 and, on day 4 of the infection, dosed orally with 0.3 or 750 microgram Cd/kg body weight, with 109Cd as a tracer, in order to study intestinal absorption and tissue distribution of Cd during infection (Experiment 1). Other mice were dosed with 0.3 microgram Cd/kg body weight 3 days before being infected and, on day 4 of the infection, Cd redistribution was studied (Experiment 2). In both experiments non-infected control animals received the same treatment as infected animals. Results showed that the infected animals had a higher gastrointestinal absorption of Cd than noninfected animals when Cd was administered during infection. In the infected animals the absorption at the low Cd dosage was increased by 70% and was tripled at the high dosage. The increased absorption enhanced the accumulation of Cd in all organs studied. Moreover, the infection caused a Cd dose-dependent change in the organ distribution of Cd, when Cd was administered during the infection. However, no redistribution of previously accumula...Continue Reading

References

May 1, 1992·Toxicology and Applied Pharmacology·N G IlbäckG Friman
Jan 1, 1992·Toxicology·N G IlbäckA W Glynn
Aug 1, 1990·Journal of Neurochemistry·J HidalgoA Armario
Oct 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J Cousins, A S Leinart
Feb 1, 1989·Current Opinion in Immunology·K J Tracey, A Cerami
Aug 1, 1989·Toxicology and Applied Pharmacology·D Goon, C D Klaassen
Feb 1, 1982·The American Journal of Clinical Nutrition·W R Beisel
Jan 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J T ZelikoffD Gardner
Dec 1, 1995·European Heart Journal·N G IlbäckG Friman
May 16, 1997·Toxicology Letters·Y Lind, A Wicklund Glynn
Feb 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A RossiM L Scarino

❮ Previous
Next ❯

Citations

Jun 15, 2007·Critical Reviews in Food Science and Nutrition·Nils-Gunnar Ilbäck, Göran Friman
Sep 4, 2008·Journal of Pharmacological and Toxicological Methods·Nils-Gunnar IlbäckGöran Friman
Jun 21, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Nils-Gunnar IlbäckGöran Friman
Feb 24, 2007·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Peter FriskNils-Gunnar Ilbäck
Sep 25, 2007·Environmental Research·Peter FriskNils-Gunnar Ilbäck
Oct 30, 2018·European Journal of Dentistry·Lubaba A Abdul AmeerAzza Wala Aldeen Khairi
Jan 1, 2005·Toxicology Mechanisms and Methods·Richa ShrivastavaU C Chaturvedi
Nov 28, 2020·Toxicology Letters·Aleksandra Popov AleksandrovMilena Kataranovski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.