The intracellular fate of Histoplasma capsulatum in human macrophages is unaffected by recombinant human interferon-gamma

The Journal of Infectious Diseases
J FleischmannD H HOWARD

Abstract

Human alveolar, peritoneal, and cultured macrophages were exposed in vitro to human recombinant interferon-gamma (rHuIFN-gamma) and were tested for their ability to inhibit intracellular replication of yeast-phase Histoplasma capsulatum. Exposure at various concentrations, and for different time periods, failed to activate the macrophages to inhibit multiplication of intracellular yeast. Macrophages were, however, activated by rHuIFN-gamma as shown by their ability to inhibit intracellular replication of Trypanosoma cruzi and by their enhanced production of superoxide when stimulated by phorbol myristate acetate. These data indicate that rHuIFN-gamma by itself does not activate human macrophages to inhibit intracellular proliferation of yeast-phase H. capsulatum.

Citations

Aug 1, 1990·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G S Deepe, W E Bullock
Aug 1, 1995·Current Opinion in Immunology·L Romani, D H Howard
Aug 28, 1998·Research in Immunology·G S Deepe, R A Seder
Mar 19, 1999·Trends in Microbiology·S L Newman
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·T J WalshJ R Graybill
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·Y FukazawaP Puccetti
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Karen L WoodHomer L Twigg
Mar 20, 2013·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Antonio Ernesto González-GonzálezMaria Lucia Taylor
Jan 1, 1994·Biotherapy·B J Kullberg, J W van 't Wout
Aug 4, 2015·The FEBS Journal·Andrew L Garfoot, Chad A Rappleye
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L A GildeaS L Newman
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon L NewmanRandall E Morris
Jan 27, 2018·Journal of Fungi·Marco J Hernández-ChávezHéctor M Mora-Montes
Feb 24, 2001·Medical Mycology·A Porta, B Maresca
Oct 1, 1992·Infection and Immunity·N M AmpelJ N Galgiani
Nov 28, 2002·International Journal of Medical Microbiology : IJMM·Atanas Ignatov, Elizabeth J Keath

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