The intracerebral hemorrhage acutely decreasing arterial pressure trial II (ICH ADAPT II) protocol

BMC Neurology
Laura C GioiaKenneth S Butcher

Abstract

Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resonance imaging (MRI) studies have demonstrated sub-acute ischemic lesions in ICH patients. The primary aim of this study is to assess ischemic lesion development in patients randomized to two different BP treatment strategies. We hypothesize aggressive BP reduction is not associated with ischemic injury after ICH. The Intracerebral Hemorrhage Acutely Decreasing Blood Pressure Trial II (ICH ADAPT II) is a phase II multi-centre randomized open-label, blinded-endpoint trial. Acute ICH patients (N = 270) are randomized to a systolic blood pressure (SBP) target of <140 or <180 mmHg. Acute ICH patients within 6 h of onset and two SBP measurements ≥140 mmHg recorded >2 mins apart qualify. SBP is managed with a pre-defined treatment protocol. Patients undergo MRI at 48 h, Days 7 and 30, with clinical assessment at Day 30 and 90. The primary outcome is diffusion weighted imaging (DWI) lesion frequency at 48 h. Secondary outcomes include cumulative DWI lesion rate frequency within 30 days, absolute hematoma growth, prediction of DWI le...Continue Reading

Associated Clinical Trials

References

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Citations

Apr 11, 2018·Current Hypertension Reports·Iryna Lobanova, Adnan I Qureshi
Dec 1, 2017·F1000Research·Stacy Chu, Lauren Sansing
Feb 9, 2019·Pharmacotherapy·Caroline Der-NigoghossianJason Makii
Nov 19, 2017·Current Vascular Pharmacology·Agata BuonaceraLorenzo Malatino
Apr 18, 2018·The Cochrane Database of Systematic Reviews·Rustam Al-Shahi SalmanNikola Sprigg
Aug 20, 2018·Current Treatment Options in Neurology·Mollie McDermott, Cemal B Sozener
Jun 6, 2018·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Massimo SalvettiMaria Lorenza Muiesan
May 28, 2019·Journal of the American Heart Association·Ana C KlahrKenneth S Butcher
May 26, 2021·Neurology·Maximiliano A Hawkes, Alejandro A Rabinstein

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Methods Mentioned

BETA
dissection

Clinical Trials Mentioned

NCT02281838

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