The intradermal effects of the H3 receptor agonist R alpha methylhistamine in human skin

The British Journal of Dermatology
G M KavanaghC B Archer

Abstract

We have investigated the possible existence of the H3 histamine receptor in human skin with the highly selective ligands R alpha methylhistamine (RAMHA) (H3 agonist) and thioperamide (H3 antagonist). We compared the intradermal effects of RAMHA with histamine, and studied their potential modulation by the H1 antagonist terfenadine, and H2 antagonist cimetidine. The effects of RAMHA and thioperamide on codeine phosphate-, substance P- and histamine-induced weal and flare responses were also studied. RAMHA produced dose-related weal and flare responses that were approximately 10- and fivefold less, respectively, than responses to histamine. Flare responses to RAMHA were significantly inhibited by oral terfenadine (P < 0.05). Weal and flare responses to histamine after oral cimetidine showed much intersubject variation, and cimetidine did not significantly alter either RAMHA- or histamine-induced weal and flare responses. Codeine phosphate-, substance P- and histamine-induced responses were not significantly affected by concurrent administration of RAMHA. Thioperamide was not found to influence codeine phosphate-, substance P-, RAMHA- or histamine-induced effects. RAMHA induces vascular (weal and flare) responses in human skin, an...Continue Reading

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Citations

Feb 28, 2001·Journal of Pain and Symptom Management·M Krajnik, Z Zylicz
Oct 14, 2003·International Immunopharmacology·Maria Alejandra HossenChiaki Kamei
Aug 23, 2003·The British Journal of Dermatology·Y Ashida, M Denda
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman

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