The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.

Endocrinology
J F CouseKenneth S Korach

Abstract

The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain expression of the type 3 (HSD17B3) isoform, which specifically converts androstenedione to T. In ovaries, thecal interstitial (TI) cells also rely on LH to induce androgen synthesis but lack HSD17B3 and therefore secrete androgens of low biological activity. Therefore, thecal cells may possess a mechanism to repress the Leydig cell phenotype and HSD17B3 expression. E2 is known to inhibit experimentally Leydig cell function and proliferation. In the current study, we provide evidence that E2 prevents the development of functional Leydig-like cells in the murine ovary and that this action is mediated by estrogen receptor (ER) alpha. ERalpha-null (alphaERKO) female mice exhibit testis-like levels of Hsd17b3 expression in the ovaries and male-like levels of plasma T. Herein, we demonstrate that: 1) Hsd17b3 expression in alphaERKO ovaries is a primary effect of the loss of intraovarian ERalpha actions; 2) alphaERKO ovarian cel...Continue Reading

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Citations

Dec 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fuminori TaniguchiKenneth S Korach
Dec 6, 2008·Genes & Development·Jennifer SchmahlPhilippe Soriano
Sep 19, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·K MorohashiM Tanaka
Mar 28, 2009·Molecular Endocrinology·Bonnie J DerooKenneth S Korach
Sep 14, 2010·The Journal of Endocrinology·Eugenia H GouldingEdward M Eddy
Dec 17, 2014·Molecular and Cellular Endocrinology·Theresa RöhrigDavid B Wilson
Jun 18, 2010·Biology of Reproduction·Jessica D SherrillBenson T Akingbemi
Mar 15, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yukitomo AraoKenneth S Korach
Mar 28, 2013·American Journal of Physiology. Endocrinology and Metabolism·Martín CrivelloVictoria Lux-Lantos
Dec 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Paolo N CatalanoVictoria A Lux-Lantos
Feb 2, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Jie LiXianyong Lan
Jul 22, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emmi RotgersHumphrey Hung-Chang Yao
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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