The intravenous and oral pharmacokinetics of lotilaner in dogs

Parasites & Vectors
Céline E ToutainMartin Jung

Abstract

Lotilaner is a new oral ectoparasiticide from the isoxazoline class developed for the treatment of flea and tick infestations in dogs. It is formulated as pure S-enantiomer in flavoured chewable tablets (Credelio™). The pharmacokinetics of lotilaner were thoroughly determined after intravenous and oral administration and under different feeding regimens in dogs. Twenty-six adult beagle dogs were enrolled in a pharmacokinetic study evaluating either intravenous or oral administration of lotilaner. Following the oral administration of 20 mg/kg, under fed or fasted conditions, or intravenous administration of 3 mg/kg, blood samples were collected up to 35 days after treatment. The effects of timing of offering food and the amount of food consumed prior or after dosing on bioavailability were assessed in a separate study in 25 adult dogs. Lotilaner blood concentrations were measured using a validated liquid chromatography/tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic parameters were calculated by non-compartmental analysis. In addition, in vivo enantiomer stability was evaluated in an analytical study. Following oral administration in fed animals, lotilaner was readily absorbed and peak blood concentrations reached wi...Continue Reading

References

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Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen

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Citations

Nov 2, 2017·Parasites & Vectors·Daniela CavalleriSteve Nanchen
Nov 2, 2017·Parasites & Vectors·Susan E Little
Jul 14, 2018·Parasites & Vectors·Céline E ToutainMartin Jung
Nov 2, 2017·Parasites & Vectors·Emmanuelle A Kuntz, Srinivas Kammanadiminti
Dec 29, 2020·Bioorganic & Medicinal Chemistry·Itamar Luís GonçalvesAloir Antonio Merlo
Mar 19, 2021·Journal of Veterinary Pharmacology and Therapeutics·Xueying ZhouWalter H Hsu
Dec 5, 2019·BMJ Global Health·Hannah R MeredithLaith Yakob
Aug 2, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Roberto González SalinasHugo Quiroz-Mercado

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