The intravestibular source of the vestibular aqueduct: Its structure and pathology in Ménière's disease

Acta Oto-laryngologica
L MichaelsF H Linthicum

Abstract

We describe a thin, highly vascular layer of mineralized cartilage, which surrounds most of the endolymphatic duct. In the normal ear this may act in helping to control the chemical composition of endolymph. In Ménière's disease (MD) there is a marked apoptotic change among the mineralized cartilage cells of this layer, which seems to be associated also with the deposition of a pathological substance in the walls of many blood vessels. This may lead to serious chemical change in the nearby endolymph and so provoke the symptoms of MD. Endolymphatic hydrops is found in all cases of MD, but is not specific for that condition. We sought a cellular change in the vicinity of the saccule that might be more specific than the lesion of endolymphatic hydrops and thus lead to a more successful management of the disease. We examined stained step sections of 33 autopsy temporal bones from 20 cases of MD, particularly in the region of the vestibule, and compared the changes with those found in a similar region of 65 temporal bones taken from randomly selected cases of non-Ménière conditions. In all temporal bones there was a well-demarcated region of the posterior vestibule, which formed a skeletal arch around the opening of the tunnel of th...Continue Reading

References

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Citations

Dec 15, 2010·Acta Oto-laryngologica·Leslie Michaels, Sava Soucek
Dec 7, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Leslie Michaels, Sava Soucek
Mar 2, 2021·Journal of Vestibular Research : Equilibrium & Orientation·Michael EliezerCharlotte Hautefort
Nov 14, 2018·Journal of Neuroradiology. Journal De Neuroradiologie·Arnaud AttyéAlexandre Krainik
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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