PMID: 7541629Sep 1, 1994Paper

The intricacies of beta-globin gene expression

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
C Andrin, C Spencer

Abstract

Gene expression is an extremely complicated process in which several mechanisms are involved. Owing to its developmental and tissue-specific expression, the beta-globin gene is an excellent model for studying gene expression. beta-Globin gene expression involves an interplay between several different mechanisms. Chromatin structure is thought to be altered by the locus control region (LCR) located far upstream of the beta-globin gene locus. As well, multiple transcription factors come into play both in the LCR and in the individual promoters and enhancers of the beta-globin genes. The interaction between these then allows for delicate regulation of beta-globin gene expression. In the following review the elaborate system of beta-globin gene expression will briefly be examined.

Citations

Jun 22, 2000·Journal of Cellular Biochemistry·L TaoG Price

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