The intriguing commonality of NETosis between COVID-19 & Periodontal disease

Medical Hypotheses
Shipra Gupta, Vaibhav Sahni

Abstract

NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation of autoimmune mechanisms. Such pathophysiology finds evidence in both Periodontal disease and COVID-19. Coupled with impaired removal, NETs have been implicated in both these disease forms to promote a state of inflammation and be a source of constant harm to the tissues involved. This potentially forms groundwork to implicate Periodontal disease as predisposing towards adverse COVID-19 related outcomes.

Citations

Feb 3, 2021·Journal of Clinical Periodontology·Nadya MaroufFaleh Tamimi
Jan 5, 2021·Genome Génome / Conseil National De Recherches Canada·Rwik SenYanan Lu
Mar 14, 2021·Oral Diseases·Andressa Chang Rodrigues Fernandes da SilvaAndreia Leal Figueiredo
May 13, 2021·Journal of Dental Research·A P MeethilP S Kumar
Jul 20, 2021·Biomedical Engineering Letters·Jaesung LimChun Gwon Park
Aug 28, 2021·Clinical Oral Investigations·Shipra GuptaIsmo Räisänen
Sep 2, 2021·Expert Review of Proteomics·Timo SorsaKrishan Gauba
Sep 10, 2021·European Journal of Dentistry·Lisa BassoKerstin Gritsch
Jan 22, 2022·Molecular Oral Microbiology·Zuhair S NattoHansel M Fletcher

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Methods Mentioned

BETA
bronchoalveolar

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